国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2008年
11期
980-982
,共3页
淀粉酶类%脂肪酶%胰腺炎
澱粉酶類%脂肪酶%胰腺炎
정분매류%지방매%이선염
Amylases%Lipase%Pancreatitis
目的 为了评价急性胰腺炎中胰型淀粉酶(P-AMY)的临床应用价值,对总淀粉酶(α-AMY)、P-AMY、脂肪酶(lipase,LPS)进行方法学评价.方法 选择急性胰腺炎患者126例、其他疾病患者对照组105例、健康对照组95例,用日立7600全自动生化分析仪测定α-AMY、P-AMY、LPS.本实验室临界值定为α-AMY 216 U/L、P-AMY 115 U/L、LPS 200 U/L.结果 α-AMY、P-AMY、LPS灵敏度分别为73.1%、88.5%、92.3%,特异性分别为70.5%、81.9%、82.9%,ROC工作曲线下α-AMY、P-AMY、LPS灵敏度分别为65.4%、88.5%、88.5%,特异性分别为86.7%、80 9%、89.5%,α-AMY和P-AMY之间差异有统计学意义(P=0.045),P-AMY和LPS之间差异无统计学意义(P=0.613).结论 P-AMY检测比α-AMY更敏感、更特异性地反映急性胰腺炎.LPS也同样在急性胰腺炎中具有高灵敏度和特异性,临床上应同时检测P-AMY和LPS作为诊断急性胰腺炎的指标,具有更重要意义.
目的 為瞭評價急性胰腺炎中胰型澱粉酶(P-AMY)的臨床應用價值,對總澱粉酶(α-AMY)、P-AMY、脂肪酶(lipase,LPS)進行方法學評價.方法 選擇急性胰腺炎患者126例、其他疾病患者對照組105例、健康對照組95例,用日立7600全自動生化分析儀測定α-AMY、P-AMY、LPS.本實驗室臨界值定為α-AMY 216 U/L、P-AMY 115 U/L、LPS 200 U/L.結果 α-AMY、P-AMY、LPS靈敏度分彆為73.1%、88.5%、92.3%,特異性分彆為70.5%、81.9%、82.9%,ROC工作麯線下α-AMY、P-AMY、LPS靈敏度分彆為65.4%、88.5%、88.5%,特異性分彆為86.7%、80 9%、89.5%,α-AMY和P-AMY之間差異有統計學意義(P=0.045),P-AMY和LPS之間差異無統計學意義(P=0.613).結論 P-AMY檢測比α-AMY更敏感、更特異性地反映急性胰腺炎.LPS也同樣在急性胰腺炎中具有高靈敏度和特異性,臨床上應同時檢測P-AMY和LPS作為診斷急性胰腺炎的指標,具有更重要意義.
목적 위료평개급성이선염중이형정분매(P-AMY)적림상응용개치,대총정분매(α-AMY)、P-AMY、지방매(lipase,LPS)진행방법학평개.방법 선택급성이선염환자126례、기타질병환자대조조105례、건강대조조95례,용일립7600전자동생화분석의측정α-AMY、P-AMY、LPS.본실험실림계치정위α-AMY 216 U/L、P-AMY 115 U/L、LPS 200 U/L.결과 α-AMY、P-AMY、LPS령민도분별위73.1%、88.5%、92.3%,특이성분별위70.5%、81.9%、82.9%,ROC공작곡선하α-AMY、P-AMY、LPS령민도분별위65.4%、88.5%、88.5%,특이성분별위86.7%、80 9%、89.5%,α-AMY화P-AMY지간차이유통계학의의(P=0.045),P-AMY화LPS지간차이무통계학의의(P=0.613).결론 P-AMY검측비α-AMY경민감、경특이성지반영급성이선염.LPS야동양재급성이선염중구유고령민도화특이성,림상상응동시검측P-AMY화LPS작위진단급성이선염적지표,구유경중요의의.
Objective To investigate the clinical value of pancreatic amylase (P-AMY) in acute pancreatitis, and perform methodical evaluation on total amylase (α-AMY), P-AMY and lipase.Methods 126 cases of patients with acute pancreatitis, 105 cases of disease controls and 95 healthy controls were involced in the investigation. Hitachi7600 automatic biochemical analyzer was applying to measuring α-AMY, P-AMY and lipase. The upper limit of the reference range of the total amylase, pancreatic amylase and lipase was 216 U/L, 115 U/L and 200 U/L respectively in our laboratory.Results The sensitivity of total amylase, pancreatic amylase, and lipase for the diagnosis of acute pancreatitis was 73.1%, 88.5% and 92.3% respectively;and while the specificity was 70.5%、81.9% and 82.9% respectively. The diagnostic accuracy, determined as the area under the curve, was 0.795 for total amylase, 0.868 for pancreatic amylase, and 0.886 for lipase. There was a significant difference between the total amylase and pancreatic amylase (P=0.045), but no significant difference was found between the pancreatic amylase and lipase (P=0.613) by ROC curve.Conclusion Pancreatic amylase has a higher sensitivity, specificity and diagnostic accuracy than α-AMY in acute pancreatitis, and shows a similar diagnostic performance as lipase. Therefore, P-AMY and lipase should be measured in combination in the diagnosis of acute pancreatitis.
