CAJ | 학술논문

本文报道了新型铜配合物[Cu(PyPt)(NO_3)_2](HPyPt是N-2-吡啶基-N'-苯基硫脲)的合成、结构、波谱表征及其与DNA相互作用研究.该配合物属三斜品系P1空间群,其中a=0.761 52(15)nm,b=0.80957(16)nm,c=1.311 3(3)nm,α=76.01(3)°,β=89.59(3)°,γ=68.24(3)°,V=0.7255(2)nm3,Z=2.利用荧光光谱法、紫外光谱法和粘度法初步研究了[Cu(PyPt)(NO_3)_2]与小牛胸腺DNA的相互作用,计算其与DNA结合常数K_b为1.63×10~3 L·mol~(-1).
본문보도료신형동배합물[Cu(PyPt)(NO_3)_2](HPyPt시N-2-필정기-N'-분기류뇨)적합성、결구、파보표정급기여DNA상호작용연구.해배합물속삼사품계P1공간군,기중a=0.761 52(15)nm,b=0.80957(16)nm,c=1.311 3(3)nm,α=76.01(3)°,β=89.59(3)°,γ=68.24(3)°,V=0.7255(2)nm3,Z=2.이용형광광보법、자외광보법화점도법초보연구료[Cu(PyPt)(NO_3)_2]여소우흉선DNA적상호작용,계산기여DNA결합상수K_b위1.63×10~3 L·mol~(-1).
A novel copper(Ⅱ) complex [Cu(PyPt)(NO_3)_2] (where HPyPt=N-2-Pyridyl-N'-Phenylthiourea ligand) had been prepared and structurally characterized, its DNA binding activity had also been investigated. The complex crystallizes in the triclinic system, space group P1 with cell parameters a=0.761 52(15) nm, 6=0.809 57(16) run, c=1.311 3(3) nm, α=76.01(3)°, β=89.59(3)°, γ=68.24(3)°, V =0.725 5(2) nm~3 and Z=2. The interactions between the complex and calf thymus DNA had been investigated using fluorescent spectra, UV spectra and viscosity. The intrinsic binding constant (K_b) for complex to DNA was calculated to be 1.63×10~3 L·mol~(-1).