CAJ | 학술논문

目的观察中等强度跑台运动对去卵巢大鼠后肢骨骨矿物含量(BMC)和骨密度(BMD)的影响.方法将60只3月龄未经产雌性SD大鼠按体重随机分为假手术、去卵巢静止、去卵巢运动Ⅰ、去卵巢运动Ⅱ、去卵巢运动Ⅲ和去卵巢运动Ⅳ 6个组.各运动组经1周的跑台适应训练后,按实验设计分别进行为期14周的正式跑台训练.实验结束时,腹主动脉取血处死大鼠,双能χ-射线骨密度仪检测右侧游离股骨和胫骨的BMC和BMD.结果 ①与假手术组相比,去卵巢静止组股骨近端和远端以及胫骨近端BMC和BMD显著下降,但股骨中段以及胫骨中段和远端BMC和BMD无显著变化.②与去卵巢静止组相比,去卵巢运动Ⅰ组股骨近端和远端BMC显著增加,股骨中段以及胫骨3个部位BMC均无显著变化;去卵巢运动Ⅱ组和Ⅲ组股骨和胫骨3个部位BMC 均无显著变化;去卵巢运动Ⅳ组股骨3个部位BMC均无显著变化,而胫骨3个部位BMC均显著下降.③与去卵巢静止组相比,去卵巢运动Ⅰ组股骨近端和远端以及胫骨近端BMD 显著增加, 而股骨中段和胫骨中段和远端BMD无显著变化;去卵巢运动Ⅱ组和Ⅲ组股骨和胫骨任何部位BMD均没有显著变化;去卵巢运动Ⅳ组股骨3个部位BMD无显著变化,而胫骨3个部位BMD却显著下降.结论较低中等强度跑台运动能减缓去卵巢大鼠股骨近端和远端骨矿物含量和骨密度的下降;而较高中等强度跑台运动却能加速去卵巢大鼠胫骨近端骨矿物含量和骨密度的下降.
목적 관찰중등강도포태운동대거란소대서후지골골광물함량(BMC)화골밀도(BMD)적영향.방법 장60지3월령미경산자성SD대서안체중수궤분위가수술、거란소정지、거란소운동Ⅰ、거란소운동Ⅱ、거란소운동Ⅲ화거란소운동Ⅳ 6개조.각운동조경1주적포태괄응훈련후,안실험설계분별진행위기14주적정식포태훈련.실험결속시,복주동맥취혈처사대서,쌍능χ-사선골밀도의검측우측유리고골화경골적BMC화BMD.결과 ①여가수술조상비,거란소정지조고골근단화원단이급경골근단BMC화BMD현저하강,단고골중단이급경골중단화원단BMC화BMD무현저변화.②여거란소정지조상비,거란소운동Ⅰ조고골근단화원단BMC현저증가,고골중단이급경골3개부위BMC균무현저변화;거란소운동Ⅱ조화Ⅲ조고골화경골3개부위BMC 균무현저변화;거란소운동Ⅳ조고골3개부위BMC균무현저변화,이경골3개부위BMC균현저하강.③여거란소정지조상비,거란소운동Ⅰ조고골근단화원단이급경골근단BMD 현저증가, 이고골중단화경골중단화원단BMD무현저변화;거란소운동Ⅱ조화Ⅲ조고골화경골임하부위BMD균몰유현저변화;거란소운동Ⅳ조고골3개부위BMD무현저변화,이경골3개부위BMD각현저하강.결론 교저중등강도포태운동능감완거란소대서고골근단화원단골광물함량화골밀도적하강;이교고중등강도포태운동각능가속거란소대서경골근단골광물함량화골밀도적하강.
Objective To observe the effects of moderate intensity exercise on bone mineral content (BMC) and bone mineral density (BMD) in ovariectomized rats. Methods Sixty 3monthold female SD rats were either shamoperated (SHAM) or ovariectomized (OVX) and randomly divided into six groups by body weight: SHAM group, OVX group, exercised OVX groupⅠ, exercised OVX groupⅡ, exercised OVX groupⅢ, exercised OVX groupⅣ. After one week of adaptation training, exercise groups began official training for 14 weeks according to experimental design. At the end of the experiment, blood was collected from abdominal vein with general anesthesia. BMC and BMD of right femur and tibia were measured by dual energy X-ray absiorptiometry.Results (1) As expected, OVX resulted in loss of the proximal and distal femur as well as the proximal tibia BMC compared with the SHAM group, as well as the BMD. However, the middle femur BMC and BMD and the middle and distal tibia BMD had no significantly change. (2) The proximal and distal femur BMC increased remarkably in groupⅠas compared to OVX group, but no difference was observed in middle femur and the threesite tibia. Compared with the OVX group,any sites of the femur and tibia BMC had no significantly change in group Ⅱand Ⅲ. Any sites of the femur BMC had significant difference in group Ⅳ as compared to OVX group, while significantly decreased in tibia. (3) BMD in the proximal and distal femur and the proximal tibia were significantly increased in exercise groupⅠas compared to OVX group, but the middle femur BMD and the middle and distal tibia BMD had no significant difference. Any sites of the femur and tibia BMD had no significantly change in exercise groupⅡand Ⅲ. The exercise group Ⅳ had significantly lower tibia BMD than those of the OVX group, but no significant change was observed in the threesite femur BMD. Conclusion The lower moderatetreadmill exercise could mitigate femoral bone loss in ovariectomized rats, however, the higher moderatetreadmill exercise could fasten tibia bone loss.