CAJ | 학술논문

树突状细胞(DC)是专职抗原呈递细胞,具有强大的免疫监视功能.由于在诱导免疫反应中的重要作用,DC已被广泛地应用于抗肿瘤免疫治疗.但是由于肿瘤细胞对荷瘤宿主免疫系统,尤其是对DC功能的抑制,使以DC为基础的抗肿瘤免疫治疗疗效受到了很大的限制.所以,通过调节DC功能,可打破肿瘤对DC的免疫抑制,引导有效的抗肿瘤反应,提高以DC为基础的抗肿瘤免疫效果,这在抗肿瘤免疫治疗中具有重要意义.
수돌상세포(DC)시전직항원정체세포,구유강대적면역감시공능.유우재유도면역반응중적중요작용,DC이피엄범지응용우항종류면역치료.단시유우종류세포대하류숙주면역계통,우기시대DC공능적억제,사이DC위기출적항종류면역치료료효수도료흔대적한제.소이,통과조절DC공능,가타파종류대DC적면역억제,인도유효적항종류반응,제고이DC위기출적항종류면역효과,저재항종류면역치료중구유중요의의.
Dendritic cells(DCs),the most effective professional antigen presenting ceHs in the immune system,are able to induce and regulate different kinds of immune responses.Although DCs have been widely used in tumor immunotherapy,the DC-based therapies against tumors are limited since their function and activity are often inhibited by tumor and/or tumor associated factors.Thus.importance significant if DC ac-tivity could be regulated to resist tumor-induced suppression.In this review,we sumnlarize the current knowledge about the immune therapies by the means of breaking tumor induced suppression on DCs to en-hanee the clinical responses against cancer.