CAJ | 학술논문

目的研究所氯吡格雷对冠心病患者阿司匹林抵抗的影响.方法筛选出冠心病患者中发生阿司匹林抵抗的患者58例入选本研究,随机分为对照组和氯吡格雷组,分别给予阿司匹林100 mg+安慰剂每天和阿司匹林100mg+氯吡格雷75mg每天,14天后采用全血电阻法检测血小板聚集功能.结果与对照组相比,氯吡格雷组使ADP(二磷酸腺苷)诱导的血小板聚集功能显著抑制[(1.3±0.48)Ω比(12.8±2.5)Ω],P<0.01,但对从(花生四烯酸)诱导的血小板聚集没有影响[(12.3±4.3)Ω比(11.9土4.9)Ω],P>0.05.结论合用氯吡格雷不能完全改善冠心痛患者的阿斯匹林抵抗,对这部分患者应加强综合治疗.
목적 연구소록필격뢰대관심병환자아사필림저항적영향.방법 사선출관심병환자중발생아사필림저항적환자58례입선본연구,수궤분위대조조화록필격뢰조,분별급여아사필림100 mg+안위제매천화아사필림100mg+록필격뢰75mg매천,14천후채용전혈전조법검측혈소판취집공능.결과 여대조조상비,록필격뢰조사ADP(이린산선감)유도적혈소판취집공능현저억제[(1.3±0.48)Ω비(12.8±2.5)Ω],P<0.01,단대종(화생사희산)유도적혈소판취집몰유영향[(12.3±4.3)Ω비(11.9토4.9)Ω],P>0.05.결론 합용록필격뢰불능완전개선관심통환자적아사필림저항,대저부분환자응가강종합치료.
Objective To study effects of clopidogrel on aspirin resistance of patients with coronary atherosclerotic heart disease.Methods 58 patients with coronary atherosclerotic heart disease who were diagnosed aspirin resistance were randomly divided into control group and clopidogrel group,which were given aspirin 100mg +placebo per day and aspirin 100mg+clopigrel 75mg per day respectively.The platelet aggregation was ana-lyzed by the method of whole blood electric resistance.Results The platelet aggregation function induced by adenosine diphosphate (ADP) was suppressed significantly by clopdogrel group contrast to control group [(1.3±0.48) Ω vs (12.8±2.5) Ω,P<O.O1],but there was no difference in The platelet aggregation function induced by arachidonic acid (AA) between two groups[(12.3 ±4.3) Ω vs (11.9 ±4.9) Ω,P>O.O5].Conclusions Clopidogrel can't retrieve aspirin resistance of patients with coronary heart disease completely,they should be strengthened combination therapy.