中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2008年
9期
610-612
,共3页
潘解萍%吴敏%马英淳%孙茹蓉
潘解萍%吳敏%馬英淳%孫茹蓉
반해평%오민%마영순%손여용
关节炎,类风湿%软骨寡聚基质蛋白%酶联免疫吸附试验
關節炎,類風濕%軟骨寡聚基質蛋白%酶聯免疫吸附試驗
관절염,류풍습%연골과취기질단백%매련면역흡부시험
Arthritis rheumatoid%Cartilage oligomerie matrix protein%Enzyme-linked immunosor-bent assay
目的 探讨检测软骨寡聚基质蛋白(COMP)水平对类风湿关节炎(RA)患者疾病活动性及早期软骨破坏的临床意义.方法 采用酶联免疫吸附试验(ELISA)法,检测94例RA患者及40名健康人血清中COMP的水平.同时测定RA患者的其他实验室及临床指标:类风湿因子(RF)、红细胞沉降率(ESR)、C反应蛋白(CRP)、抗环瓜氨酸肽抗体(抗CCP抗体)、压痛关节数、疼痛关节数、肿胀关节数、晨僵时间及双手X线,分析它们与COMP的相关性.结果 RA患者血清COMP水平(11.3±5.2)U/L明显高于正常对照组的(9.2±1.7)U/L;两组差异有统计学意义(p=0.017).64例RA活动期患者血清COMP水平为(14±6)U/L,30例缓解期患者为(9±4)U/L,组间比较差异有统计学意义(p=0.005).COMP水平与RA思者的ESR、CRP、晨僵时间、压痛关节数、疼痛关节数、肿胀关节数、X,线分期呈正相关(P<0.05),与年龄、病程、RF、抗CCP抗体水平、功能分级无明显关系(p＞0.05).30例RA患者完成2年放射学随访,18例COMP值大于健康者,16例X线有递增现象,2例无递增现象;而12例COMP值正常/低于健康者,有递增5例,无递增7例,两组间差异有统计学意义(p=0.013).结论 RA患者血清中COMP高水平存在提示RA疾病活动性和早期关节软骨破坏.COMP可以作为反映RA疾病急性活动程度与软骨破坏的血清学指标.
目的 探討檢測軟骨寡聚基質蛋白(COMP)水平對類風濕關節炎(RA)患者疾病活動性及早期軟骨破壞的臨床意義.方法 採用酶聯免疫吸附試驗(ELISA)法,檢測94例RA患者及40名健康人血清中COMP的水平.同時測定RA患者的其他實驗室及臨床指標:類風濕因子(RF)、紅細胞沉降率(ESR)、C反應蛋白(CRP)、抗環瓜氨痠肽抗體(抗CCP抗體)、壓痛關節數、疼痛關節數、腫脹關節數、晨僵時間及雙手X線,分析它們與COMP的相關性.結果 RA患者血清COMP水平(11.3±5.2)U/L明顯高于正常對照組的(9.2±1.7)U/L;兩組差異有統計學意義(p=0.017).64例RA活動期患者血清COMP水平為(14±6)U/L,30例緩解期患者為(9±4)U/L,組間比較差異有統計學意義(p=0.005).COMP水平與RA思者的ESR、CRP、晨僵時間、壓痛關節數、疼痛關節數、腫脹關節數、X,線分期呈正相關(P<0.05),與年齡、病程、RF、抗CCP抗體水平、功能分級無明顯關繫(p＞0.05).30例RA患者完成2年放射學隨訪,18例COMP值大于健康者,16例X線有遞增現象,2例無遞增現象;而12例COMP值正常/低于健康者,有遞增5例,無遞增7例,兩組間差異有統計學意義(p=0.013).結論 RA患者血清中COMP高水平存在提示RA疾病活動性和早期關節軟骨破壞.COMP可以作為反映RA疾病急性活動程度與軟骨破壞的血清學指標.
목적 탐토검측연골과취기질단백(COMP)수평대류풍습관절염(RA)환자질병활동성급조기연골파배적림상의의.방법 채용매련면역흡부시험(ELISA)법,검측94례RA환자급40명건강인혈청중COMP적수평.동시측정RA환자적기타실험실급림상지표:류풍습인자(RF)、홍세포침강솔(ESR)、C반응단백(CRP)、항배과안산태항체(항CCP항체)、압통관절수、동통관절수、종창관절수、신강시간급쌍수X선,분석타문여COMP적상관성.결과 RA환자혈청COMP수평(11.3±5.2)U/L명현고우정상대조조적(9.2±1.7)U/L;량조차이유통계학의의(p=0.017).64례RA활동기환자혈청COMP수평위(14±6)U/L,30례완해기환자위(9±4)U/L,조간비교차이유통계학의의(p=0.005).COMP수평여RA사자적ESR、CRP、신강시간、압통관절수、동통관절수、종창관절수、X,선분기정정상관(P<0.05),여년령、병정、RF、항CCP항체수평、공능분급무명현관계(p＞0.05).30례RA환자완성2년방사학수방,18례COMP치대우건강자,16례X선유체증현상,2례무체증현상;이12례COMP치정상/저우건강자,유체증5례,무체증7례,량조간차이유통계학의의(p=0.013).결론 RA환자혈청중COMP고수평존재제시RA질병활동성화조기관절연골파배.COMP가이작위반영RA질병급성활동정도여연골파배적혈청학지표.
Objective To study the association of serum cartilage oligomeric matrix protein (COMP)with disease activity and early joint destruction of rheumatoid arthritis (RA). Methods The serum levels of COMP were measured with ELISA in 94 patients with RA and 40 controls. The serum level of erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (ACCP) and hand X-ray were examined at the same time. Results Significantly increased serum level of COMP was found in RA patients (11.3±5.2) U/L as compared to that in healthy controls (9.2±1.7) U/L (P=0.017).Serum level of COMP was higher in 64 active patients (14±6) U/L than that in 30 inactive disease (9±4) U/L(P=0.005). COMP level was positively correlated with the number of the affected joints, X-ray stage, CRP and ESR level (P<0.05); but had no correlation with age, disease course, grade of joint function, RF and ACCP levels. Thirty patients were followed for two years and their radiographic changes were evaluated at the baseline and the end of this study. Sixteen of 18 patients with high concentration serum COMP level had radi-ologic progression, but only 5 of 12 patients with no increase of serum COMP had radiologic progression. A significant difference (P=0.013) was founded in the two groups. Conclusion The present data suggests that the level of COMP is high in patients with RA. High serum levels of COMP indicate high disease activity and early progressive of bone destruction in RA patients. We can us COMP as a laboratory marker of RA.
