中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
12期
1238-1240
,共3页
梁文同%范丽芳%王敬%贾志强%谢旭磊%颜晓燕%李琳%贾士强%刘风珍
樑文同%範麗芳%王敬%賈誌彊%謝旭磊%顏曉燕%李琳%賈士彊%劉風珍
량문동%범려방%왕경%가지강%사욱뢰%안효연%리림%가사강%류풍진
类风湿性关节炎%可溶性细胞间粘附分子-1%99Tcm-MDP显像
類風濕性關節炎%可溶性細胞間粘附分子-1%99Tcm-MDP顯像
류풍습성관절염%가용성세포간점부분자-1%99Tcm-MDP현상
Rheumatoid arthritis%Soluble intercellular adhesion molecule-1%99Tcm-MDP scintigraphy
目的 研究类风湿性关节炎(RA)患者血清可溶性细胞间粘附分子-1(sICAM-1)水平变化及其与99Tcm-MDP骨关节显像的相关性,探讨在本病早期诊断中的意义.方法 用ELISA法检测达标组(23例)、非达标组(28例)及对照组(20例)血清sICAM-1水平.以99Tcm MDP为示踪剂,对上述3组受检者行核素骨关节显像,进行肉眼定性及半定量分析.结果 达标组、非达标组血清sICAM-1水平明显高于对照组(P<0.01和P<0.05),达标组与非达标组比较,血清sICAM-1水平差异无统计学意义(P>0.05).非达标组、达标组血清sICAM-1水平与手足关节指数有相关性(P<0.01或P<0.05).达标组、非达标组手、足、腕、踝病变关节放射性浓聚明显高于对照组.结论 检测血清sICAM-1水平及99Tcm-MDP骨关节显像定性、半定量分析,有助于类风湿性关节炎患者,尤其是早期进行诊断及判断病情活动程度,改善预后.
目的 研究類風濕性關節炎(RA)患者血清可溶性細胞間粘附分子-1(sICAM-1)水平變化及其與99Tcm-MDP骨關節顯像的相關性,探討在本病早期診斷中的意義.方法 用ELISA法檢測達標組(23例)、非達標組(28例)及對照組(20例)血清sICAM-1水平.以99Tcm MDP為示蹤劑,對上述3組受檢者行覈素骨關節顯像,進行肉眼定性及半定量分析.結果 達標組、非達標組血清sICAM-1水平明顯高于對照組(P<0.01和P<0.05),達標組與非達標組比較,血清sICAM-1水平差異無統計學意義(P>0.05).非達標組、達標組血清sICAM-1水平與手足關節指數有相關性(P<0.01或P<0.05).達標組、非達標組手、足、腕、踝病變關節放射性濃聚明顯高于對照組.結論 檢測血清sICAM-1水平及99Tcm-MDP骨關節顯像定性、半定量分析,有助于類風濕性關節炎患者,尤其是早期進行診斷及判斷病情活動程度,改善預後.
목적 연구류풍습성관절염(RA)환자혈청가용성세포간점부분자-1(sICAM-1)수평변화급기여99Tcm-MDP골관절현상적상관성,탐토재본병조기진단중적의의.방법 용ELISA법검측체표조(23례)、비체표조(28례)급대조조(20례)혈청sICAM-1수평.이99Tcm MDP위시종제,대상술3조수검자행핵소골관절현상,진행육안정성급반정량분석.결과 체표조、비체표조혈청sICAM-1수평명현고우대조조(P<0.01화P<0.05),체표조여비체표조비교,혈청sICAM-1수평차이무통계학의의(P>0.05).비체표조、체표조혈청sICAM-1수평여수족관절지수유상관성(P<0.01혹P<0.05).체표조、비체표조수、족、완、과병변관절방사성농취명현고우대조조.결론 검측혈청sICAM-1수평급99Tcm-MDP골관절현상정성、반정량분석,유조우류풍습성관절염환자,우기시조기진행진단급판단병정활동정도,개선예후.
Objective To study serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and its correlation with accumulation degree of 99Tcm-MDP on bone and arthritis and to study the role of sICAM-1 in the diagnosis of patients with early RA. Methods Serum levels of sICAM-1 were measured by immunoenzymetic assay (ELISA). 99mTc-MDP scintigraphy was carried out for the same patients. The significant test between serum levels of sICAM-1 of three groups was performed with analysis of variance; Correlations between serum levels of sICAM-1 and index of semiquatitive 99Tcm-MDP were obtained using sperman's ranks correlation method. Results Compared with control group,serum levels of sICAM-1 were significantly higher in standard group (group A) (P<0.01) and non-standard group (group B) (P<0.05). No significant difference was found between group A and B(P>0.05). Serum levels of sICAM-1 were positively correlated with 99Tcm-MDP scintigraphy. Most patients of non-standard group and standard group showed visible medium-high uptake of 99Tcm-MDP. While control group had not obviously uptake of 99Tcm-MDP. Conclusion Serum levels of sICAM-1, semiquatitive 99Tcm-MDP scintigraphy, accumulation degree of radiopharmuceuutial on bone and arthritis are helpful for diagnosis of early rheumatoid arthritis and judge-ment of the clinical status and improvement of the prognosis.
