CAJ | 학술논문

目的探讨FXYD3蛋白组在肝门胆管癌组织的表达及其与临床病理学特征的关系.方法采用免疫组织化学链酶亲和素-生物素-过氧化物酶复合物(SABC)法检测43例肝门胆管癌及相应癌旁组织中FXYD3蛋白的表达,分析FXYD3表达与肿瘤临床病理学特征的关系.结果胆管癌组FXYD3蛋白表达阳性率为67.44％( 29/43)显著高于癌旁组32.56％( 14/43,P＜0.01),且前者的FXYD3蛋白表达与其组织分化程度明显相关(P＜0.01),与患者年龄、性别、肿瘤TNM分期及糖链抗原(CA19-9)的表达无明显相关(P＞0.05).结论 FXYD3蛋白表达与肝门胆管癌组织分化程度密切相关,可能在肿瘤细胞初始转化及发生发展过程中起重要作用.
목적 탐토FXYD3단백조재간문담관암조직적표체급기여림상병이학특정적관계.방법 채용면역조직화학련매친화소-생물소-과양화물매복합물(SABC)법검측43례간문담관암급상응암방조직중FXYD3단백적표체,분석FXYD3표체여종류림상병이학특정적관계.결과 담관암조FXYD3단백표체양성솔위67.44％( 29/43)현저고우암방조32.56％( 14/43,P＜0.01),차전자적FXYD3단백표체여기조직분화정도명현상관(P＜0.01),여환자년령、성별、종류TNM분기급당련항원(CA19-9)적표체무명현상관(P＞0.05).결론 FXYD3단백표체여간문담관암조직분화정도밀절상관,가능재종류세포초시전화급발생발전과정중기중요작용.
Objective To investigate the expression of FXYD3 protein in hilar cholangiocarcinoma and the relationship of FXYD3 protein expression with the biological characteristics of hilar cholangiocarcinoma cells.Methods Strept avidin-biotin complex (SABC) immunohistochemical method was used to detect the expression of FXYD3 protein in 43 hilar cholangiocarcinoma and paraneoplastic tissues respectively.The relationship of FXYD3 protein expression with the biological characteristics of hilar cholangiocarcinoma cells was analyzed.Results The positive expression rate of FXYD3 protein in hilar cholangiocarcinoma was 67.44％ (29/43),significantly higher than that of 32.56％ ( 14/43 ) in paraneoplastic tissue (P＜ 0.01 ).FXYD3 protein expression was significantly correlated with the histological classification (P ＜ 0.01 ),but not with patient' s age,gender,TNM stage and casbohydrate antigen19-9 (CA19-9) expression (P ＞ 0.05).Conclusion FXYD3 protein expression was significantly correlated with the histological classification,suggesting it may be a very critical factor in primary cell transformation and progress of hilar cholangiocarcinoma.