CAJ | 학술논문

目的分析儿童青少年垂体催乳素(PRL)瘤的临床特点和治疗情况.方法回顾性总结31例儿童青少年垂体PRL瘤患者的临床特点,包括患者性别、年龄、临床表现、影像学特点、激素水平以及治疗情况.结果本组男女比例1:2,诊断年龄(16.9±2.7)岁,发病年龄(15.0±2.7)岁.女性患者以月经异常,男性以头痛和视力障碍为主要临床表现.其中81%为大腺瘤,血PRL水平与腺瘤长径正相关(r=0.5252,p=0.0145).29%接受手术治疗的患者和64%的药物治疗患者随访2-18个月,PRL水平正常.结论儿童青少年垂体PRL瘤与成人相比男性患者比例显著升高,大多数为垂体大肿瘤,多于青春发育后起病,多巴胺激动剂治疗安全有效.
목적 분석인동청소년수체최유소(PRL)류적림상특점화치료정황.방법 회고성총결31례인동청소년수체PRL류환자적림상특점,포괄환자성별、년령、림상표현、영상학특점、격소수평이급치료정황.결과 본조남녀비례1:2,진단년령(16.9±2.7)세,발병년령(15.0±2.7)세.녀성환자이월경이상,남성이두통화시력장애위주요림상표현.기중81%위대선류,혈PRL수평여선류장경정상관(r=0.5252,p=0.0145).29%접수수술치료적환자화64%적약물치료환자수방2-18개월,PRL수평정상.결론 인동청소년수체PRL류여성인상비남성환자비례현저승고,대다수위수체대종류,다우청춘발육후기병,다파알격동제치료안전유효.
Objective To study the clinical characteristics and treatment of pituitary prolactinoma in children and adolescents. Method The clinical data of 31 prolactinoma patients treated from 2002 to 2007 in PUMC hospital were reviewed retrospectively. Results The group of patients consisted of(21±67.7)% girls and(10±32.3)% boys.The average age at diagnosis was 16.9±2.7 years old. The onset age was 15.0±2.7 years. The main symptoms were abnormal menstruation in girls and headache and visual disorders in boys. 81% patients had macroadenomas. The baseline level of serum prolactin was positively correlated with the size of tumor.13% patients had secondary hypothyroidism and 24% patients with lower levels of cortisol and ACTH.29% patients were treated with transsphenoidal surgery.The level of PRL maintained normal in 29% patients 2 to 18 months later after operation and in 64% patients treated with bromocriptine.Conclusion Compared with adults,the percentage of male is higher in children and adolescents prolactinoma patients and there are more macroadenomas. Dopamine agonist is effective and safe for these patients.