肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2011年
12期
822-824
,共3页
陈少斌%杨捷生%杨卫平%翁鸿锐%李桦%刘迪填%陈于平
陳少斌%楊捷生%楊衛平%翁鴻銳%李樺%劉迪填%陳于平
진소빈%양첩생%양위평%옹홍예%리화%류적전%진우평
食管肿瘤%癌,小细胞%治疗%预后
食管腫瘤%癌,小細胞%治療%預後
식관종류%암,소세포%치료%예후
Esophageal neoplasms%Carcinoma,small cell%Treatment%Prognosis
目的 分析局限期原发性食管小细胞癌( PESC)的临床特点及其诊断、治疗及预后.方法 回顾性分析1990年11月至2010年12月汕头大学医学院附属肿瘤医院收治的以手术为主治疗的局限期PESC患者42例临床资料,采用Kaplan-Meier法进行生存分析.结果 PESC的临床症状、影像学表现和内窥镜下表现与食管鳞状细胞癌相似.26例患者术前行胃镜活组织检查,5例病理诊断为小细胞癌,21例误诊为鳞状细胞癌.全组患者随访0 ~ 123个月,平均随访25.3个月,34例死亡,7例生存,1例失访.中位生存时间13.0个月(95%可信区间6.3 ~ 19.7个月).0.5、1、2、3、5年生存率分别为78.6%、57.5%、30.8%、23.7%、10.5%.结论 PESC罕见,胃镜活组织检查病理易误诊,治疗效果差,目前尚无标准治疗模式.
目的 分析跼限期原髮性食管小細胞癌( PESC)的臨床特點及其診斷、治療及預後.方法 迴顧性分析1990年11月至2010年12月汕頭大學醫學院附屬腫瘤醫院收治的以手術為主治療的跼限期PESC患者42例臨床資料,採用Kaplan-Meier法進行生存分析.結果 PESC的臨床癥狀、影像學錶現和內窺鏡下錶現與食管鱗狀細胞癌相似.26例患者術前行胃鏡活組織檢查,5例病理診斷為小細胞癌,21例誤診為鱗狀細胞癌.全組患者隨訪0 ~ 123箇月,平均隨訪25.3箇月,34例死亡,7例生存,1例失訪.中位生存時間13.0箇月(95%可信區間6.3 ~ 19.7箇月).0.5、1、2、3、5年生存率分彆為78.6%、57.5%、30.8%、23.7%、10.5%.結論 PESC罕見,胃鏡活組織檢查病理易誤診,治療效果差,目前尚無標準治療模式.
목적 분석국한기원발성식관소세포암( PESC)적림상특점급기진단、치료급예후.방법 회고성분석1990년11월지2010년12월산두대학의학원부속종류의원수치적이수술위주치료적국한기PESC환자42례림상자료,채용Kaplan-Meier법진행생존분석.결과 PESC적림상증상、영상학표현화내규경하표현여식관린상세포암상사.26례환자술전행위경활조직검사,5례병리진단위소세포암,21례오진위린상세포암.전조환자수방0 ~ 123개월,평균수방25.3개월,34례사망,7례생존,1례실방.중위생존시간13.0개월(95%가신구간6.3 ~ 19.7개월).0.5、1、2、3、5년생존솔분별위78.6%、57.5%、30.8%、23.7%、10.5%.결론 PESC한견,위경활조직검사병리역오진,치료효과차,목전상무표준치료모식.
Objective To investigate the clinical characteristics,diagnosis,treatment and prognosis of limited stage primary esophageal small cell carcinoma (PESC).Methods Clinical data was retrospectively analyzed for 42 patients with pathologically confirmed PESCs who underwent transthoracic esophagectomy with lymphadenectomy from Nov.1990 to Dec.2010 at the Cancer Hospital of Shantou University Medical College.The survival analysis was performed using Kaplan-Meier method.Results The clinical symptoms,imaging and endoscopic features of PESC were similar to those of esophageal squamous cell carcinoma (ESCC).Of the 26 cases that received pre-operative endoscopic biopsy,only five cases were diagnosed as PESC,while the other 21 cases were misdiagnosed as ESCC.The mean follow-up time of this series was 25.3 months (0-123 months).34 patients died of the disease during the follow-up; 7 were still alive and 1 was lost.The median survival time (MST) of the 41 patients was 13.0 months (95 % confidence interval 6.3-19.7),and the 6-,12-,24-,36-,and 60-month overall survival rates (OS) were 78.6 %,57.5 %,30.8 %,23.7 %,10.5 %,respectively.Conclusion PESC is a rare disease with poor prognosis,and is prone to be misdiagnosed by endoscopic biopsy.Currently no standard treatment has been established.