CAJ | 학술논문

近年多项研究认为慢性胃病脾胃湿热证与热休克蛋白70(HSP70)核因子-κB(Nuclear factor-kappa B,NF-κB)存有密切关系,HSP70能够维持细胞自稳,提高机体对肿瘤及外来多种病原体的免疫功能.在幽门螺杆菌(Hp)刺激下胃黏膜中NF-κB表达增多并引起炎症反应,炎症因子又可引起NF-κB表达的增多,从而引起并扩大胃黏膜的损伤.研究表明HSP 70能够阻滞NF-κB的激活与表达.在Hp相关慢性胃病脾胃湿热证与HSP70可能体现了中医"正气"的作用,NF-κB可能体现了中医"邪气"的作用,两者在脾胃湿热证中的表达可能体现了脾胃湿热证"正邪交争"的状态.
근년다항연구인위만성위병비위습열증여열휴극단백70(HSP70)핵인자-κB(Nuclear factor-kappa B,NF-κB)존유밀절관계,HSP70능구유지세포자은,제고궤체대종류급외래다충병원체적면역공능.재유문라간균(Hp)자격하위점막중NF-κB표체증다병인기염증반응,염증인자우가인기NF-κB표체적증다,종이인기병확대위점막적손상.연구표명HSP 70능구조체NF-κB적격활여표체.재Hp상관만성위병비위습열증여HSP70가능체현료중의"정기"적작용,NF-κB가능체현료중의"사기"적작용,량자재비위습열증중적표체가능체현료비위습열증"정사교쟁"적상태.
It has been proved in recent studies that the chronic gastric disease (CGD) of Pi-Wei dampheat syndrome type (CGD-PWDH) is closely related with heat shock protein 70 (HSP70) and nuclear factorkappa B (NF-κB). HSP70 can protect the auto-stability of cells and elevate the immune function in organism against tumor or multiple exogenous pathogens. Increasing of NF-κB expression presents in case of Helicobacter pylori (Hp) stimulation, it could induce inflammatory reaction, while inflammation factors could act inversely to enhance the expression of NF-κB, thus to cause and expand the damage of gastric mucosa. In addition, HSP shows blocking effect on the activation and expression of NF-κB. So, the author considered that in patients of Hp associated CGD-PEDH, HSP 70 exhibits the effect as that of "vital energy" and NF-κB play a role as the "evil qi" in Chinese medicine, the expressions of the two may embody the vital-evil combating manner of Pi-Wei damp-heat syndrome.