中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2008年
2期
92-98
,共7页
谢瑞莲%管晓翔%陈龙邦%王靖华%柏建岭%朱宝立%周晓军
謝瑞蓮%管曉翔%陳龍邦%王靖華%柏建嶺%硃寶立%週曉軍
사서련%관효상%진룡방%왕정화%백건령%주보립%주효군
乳腺肿瘤%蛋白质p27%肿瘤转移%预后%Meta分析
乳腺腫瘤%蛋白質p27%腫瘤轉移%預後%Meta分析
유선종류%단백질p27%종류전이%예후%Meta분석
Breast neoplasms%Protein p27%Neoplasm metastasis%Prognosis%Metaanalysis
目的 评价乳腺癌患者p27Kip1蛋白表达与其预后的关系.方法 计算机检索相关文献,按纳入和排除标准筛选文献,采用Revman 4.2软件进行Meta分析,并按是否淋巴结转移进行分层分析.结果 有20篇文献符合要求,包括患者人数共6457个.对乳腺癌患者总生存率合并风险比(RR)值为2.07[1.66,2.60](P＜0.01),无病生存率合并RR值为1.27[1.10,1.47](P＜0.05),无复发生存率合并RR值为1.49[0.92,2.42](P＞0.05);根据淋巴结转移情况进行分层分析:淋巴结阴性组总生存率合并RR值分别为1.98[1.34,2.91](P＜0.01),淋巴结阳性组总生存率合并RR值是1.92[1.31,2.82](P=0.0009);淋巴结阴性组无复发生存率合并RR值为1.28[0.45,3.65](P＞0.05);淋巴结阳性组无复发生存率合并RR值1.35[0.96,1.89](P＞0.05).结论 p27Kip1可能是乳腺癌患者总生存率、无病生存率的独立预后因素,但对无复发生存率是否有预测意义尚缺乏足够数据支持.
目的 評價乳腺癌患者p27Kip1蛋白錶達與其預後的關繫.方法 計算機檢索相關文獻,按納入和排除標準篩選文獻,採用Revman 4.2軟件進行Meta分析,併按是否淋巴結轉移進行分層分析.結果 有20篇文獻符閤要求,包括患者人數共6457箇.對乳腺癌患者總生存率閤併風險比(RR)值為2.07[1.66,2.60](P＜0.01),無病生存率閤併RR值為1.27[1.10,1.47](P＜0.05),無複髮生存率閤併RR值為1.49[0.92,2.42](P＞0.05);根據淋巴結轉移情況進行分層分析:淋巴結陰性組總生存率閤併RR值分彆為1.98[1.34,2.91](P＜0.01),淋巴結暘性組總生存率閤併RR值是1.92[1.31,2.82](P=0.0009);淋巴結陰性組無複髮生存率閤併RR值為1.28[0.45,3.65](P＞0.05);淋巴結暘性組無複髮生存率閤併RR值1.35[0.96,1.89](P＞0.05).結論 p27Kip1可能是乳腺癌患者總生存率、無病生存率的獨立預後因素,但對無複髮生存率是否有預測意義尚缺乏足夠數據支持.
목적 평개유선암환자p27Kip1단백표체여기예후적관계.방법 계산궤검색상관문헌,안납입화배제표준사선문헌,채용Revman 4.2연건진행Meta분석,병안시부림파결전이진행분층분석.결과 유20편문헌부합요구,포괄환자인수공6457개.대유선암환자총생존솔합병풍험비(RR)치위2.07[1.66,2.60](P＜0.01),무병생존솔합병RR치위1.27[1.10,1.47](P＜0.05),무복발생존솔합병RR치위1.49[0.92,2.42](P＞0.05);근거림파결전이정황진행분층분석:림파결음성조총생존솔합병RR치분별위1.98[1.34,2.91](P＜0.01),림파결양성조총생존솔합병RR치시1.92[1.31,2.82](P=0.0009);림파결음성조무복발생존솔합병RR치위1.28[0.45,3.65](P＞0.05);림파결양성조무복발생존솔합병RR치1.35[0.96,1.89](P＞0.05).결론 p27Kip1가능시유선암환자총생존솔、무병생존솔적독립예후인소,단대무복발생존솔시부유예측의의상결핍족구수거지지.
Objective To evaluate the relationship between p27Kip1 low expression in breast cancer and its prognostic implication in breast carcinoma patients.Methods All data that were associated with the study of the relationship between p27Kip1 and the prognosis for breast cancer was pooled from Cochrane library,PubMed,Embase and Medlinebase.The outcome was measured using the risk ratio(RR).Data pooling was performed by RevMan 4.2.Results 6457 patients from 20 studies were included in this metaanalysis.RR estimate of overall survival(OS)for patients with low level p27Kip1 was 2.07[1.66,2.60](P ＜ 0.01).For disease free survival(DFS),the pooled RR was 1.27[1.10,1.47](P＜0.05).The combined RR estimate of relapse free survival(RFS)for patients with low level of p27Kip1 was 1.49[0.92,2.42](P ＞ 0.05).In patients with lymph node negative breast carcinoma,the combined RR for OS and RFS were 1.98[1.34,2.91](P＜0.01)and 1.28[0.45,3.65](P＞0.05),respectively.Among the patients with lymph node positive breast carcinoma,the combined RR for OS and RFS was 1.92[1.3 1,2.82](P=0.0009)and 1.35[0.96,1.89](P＞0.05)respectively.Conclusions Low level of p27Kip1 appears to be an independent prognostic factor to OS and DFS of breast cancer patients but not to RFS.Additional studies with large patient number and widely accepted practical methods are required to derive the precise prognostic significance of p27Kip1 expression in breast cancer patients.
