CAJ | 학술논문

目的观察复发转移性乳腺癌化疗缓解后序贯内分泌治疗的疗效。方法8例复发转移性乳腺癌患者先根据既往用药给予化疗，疾病缓解后采用单药内分泌维持治疗。结果8例患者接受2-8个(中位4个)周期化疗，最佳疗效均达部分缓解，治疗持续时间为1-6个月(中位2个月)，化疗中位治疗失败时间为4个月。随访至2010年12月31日，8例患者的疾病进展时间为6-86个月(中位为13.5个月)。中位生存期21.5个月(6～ 86个月)。7例患者分别因严重的骨髓毒性、乏力或消化道反应而终止化疗，1例因紫杉醇变态反应停止化疗。结论复发转移性乳腺癌经化疗疾病缓解后，采用内分泌维持治疗可改善患者生活质量，延长有效治疗时间。
목적 관찰복발전이성유선암화료완해후서관내분비치료적료효。방법8례복발전이성유선암환자선근거기왕용약급여화료，질병완해후채용단약내분비유지치료。결과8례환자접수2-8개(중위4개)주기화료，최가료효균체부분완해，치료지속시간위1-6개월(중위2개월)，화료중위치료실패시간위4개월。수방지2010년12월31일，8례환자적질병진전시간위6-86개월(중위위13.5개월)。중위생존기21.5개월(6～ 86개월)。7례환자분별인엄중적골수독성、핍력혹소화도반응이종지화료，1례인자삼순변태반응정지화료。결론복발전이성유선암경화료질병완해후，채용내분비유지치료가개선환자생활질량，연장유효치료시간。
Objective To observe the efficacy of maintenance hormonal treatment after response to chemotherapy in advanced breast cancer. Methods 8 patients with advanced breast cancer were treated with chemotherapy, maintenance hormonal therapy were given after response to chemotherapy. The efficacy was evaluated every 2 cycles of chemotherapy and 2 months of endocrine therapy according to RECIST standard.Results 8 patients received chemotherapy for 2-8 cycles (median 4 cycles). All patients got PR, the duration of chemotherapy was 1-6 months (median 2 months), the time to failure of chemotherapy was 4 months. Until the last follow-up day (31th December 2010), the time to progression was 6-86 months (median 13.5 months).Survival was 6-86 months (median 21.5 months). Seven patients quit the chemotherapy due to severe side effects of hematologic toxicity, fatigue or nausea vomiting. One patient died because of allergy to paclitaxol.Conclusion Maintenance hormonal treatment after patients with metastatic breast cancer response to chemotherapy may prolong the duration of effective therapy and improve the QOL.