医学分子生物学杂志
醫學分子生物學雜誌
의학분자생물학잡지
FOREIGN MEDICAL SCIENCES
2010年
1期
86-89
,共4页
真核翻译起始因子3%肿瘤%表达
真覈翻譯起始因子3%腫瘤%錶達
진핵번역기시인자3%종류%표체
eukaryotic translation initiation factor 3%tumor%expression
真核翻译起始因子3是由多个亚基组成的,在真核翻译起始中发挥重要作用,近年来的研究表明其多个亚基在多种肿瘤细胞中存在异常表达的现象且与肿瘤的侵袭性、转移能力、分化程度及预后相关,使其有望成为肿瘤治疗的新靶点.
真覈翻譯起始因子3是由多箇亞基組成的,在真覈翻譯起始中髮揮重要作用,近年來的研究錶明其多箇亞基在多種腫瘤細胞中存在異常錶達的現象且與腫瘤的侵襲性、轉移能力、分化程度及預後相關,使其有望成為腫瘤治療的新靶點.
진핵번역기시인자3시유다개아기조성적,재진핵번역기시중발휘중요작용,근년래적연구표명기다개아기재다충종류세포중존재이상표체적현상차여종류적침습성、전이능력、분화정도급예후상관,사기유망성위종류치료적신파점.
The eukaryotic translation initiation factor 3(eIF-3)complex consists of multiple subunits and plays an important role in eukaryotic translation initiation.It has been found in recent years that,various subunits of eIF3 are abnormally express in tumors,which is closely related to tumor invasiveness,metastasis,differentiation,and prognosis of cancer.Therefore,eIF-3 may be hopeful as a potential anti-cancer therapeutic target.
