CAJ | 학술논문

目的观察清热祛瘀颗粒对冠心痛伴颈动脉易损斑块患者的治疗作用.方法 82例稳定性劳力型心绞痛伴颈动脉易损斑块患者中医辨证属痰热血瘀型者,随机分为清热祛瘀颗粒加西医常规治疗的试验组(41例)和采用西医常规治疗加安慰剂治疗的对照组(41例),共观察25周.采用高频超声检测颈动脉复杂斑块的数目、简单斑块的数目、斑块的Crouse积分及颈动脉内中膜的厚度,观察清热祛瘀颗粒对颈动脉斑块及血浆高敏C反应蛋白(hs-CRP)、CD40L变化及肝肾功能.结果试验组治疗后颈动脉复杂斑块的数目、斑块的Crouse积分、颈动脉内中膜的厚度较治疗前为低,差异均有统计学意义(P<0.05);颈动脉斑块的Crouse积分、颈动脉内中膜的厚度也较对照组治疗后为低,差异亦有统计学意义(P<0.05),试验组治疗后hs-CRP及CD40L与治疗前及对照组治疗后比较,差异均有统计学意义(P<0.05,P<0.01).治疗过程中未见明显不良反应.结论清热祛瘀颗粒对冠心病伴颈动脉易损斑块患者的颈动脉斑块具有一定的稳定作用.
목적 관찰청열거어과립대관심통반경동맥역손반괴환자적치료작용.방법 82례은정성로력형심교통반경동맥역손반괴환자중의변증속담열혈어형자,수궤분위청열거어과립가서의상규치료적시험조(41례)화채용서의상규치료가안위제치료적대조조(41례),공관찰25주.채용고빈초성검측경동맥복잡반괴적수목、간단반괴적수목、반괴적Crouse적분급경동맥내중막적후도,관찰청열거어과립대경동맥반괴급혈장고민C반응단백(hs-CRP)、CD40L변화급간신공능.결과 시험조치료후경동맥복잡반괴적수목、반괴적Crouse적분、경동맥내중막적후도교치료전위저,차이균유통계학의의(P<0.05);경동맥반괴적Crouse적분、경동맥내중막적후도야교대조조치료후위저,차이역유통계학의의(P<0.05),시험조치료후hs-CRP급CD40L여치료전급대조조치료후비교,차이균유통계학의의(P<0.05,P<0.01).치료과정중미견명현불량반응.결론 청열거어과립대관심병반경동맥역손반괴환자적경동맥반괴구유일정적은정작용.
Objective TO investigate the effect of Qingre Quyu Granule (QQG) for treatment of carotid vulnerable atherosclerotic plaque (CVAP) in patients with coronary heart disease (CHD). Methods Eighty-two CHD patients with stable exertional angina, complicated with CVAP and differentiated to phlegm-heat and bloodstasis syndrome type were randomly assigned to two groups equally, the test group treated by Western medical routine therapy combined with QQG, and the control group treated with Western medical routine therapy with placebo. Using high frequency ultrasonography, the number (complex and simple) and Crouse integral of CVAP and the intima-media membranous thickness of carotid artery were measured, and changes in serum levels of CD40L and high-sensitivity C-reactive protein (hs-CRP), liver and renal functions were observed. Results After treatment, significant improvement were shown in the test group in terms of complex plaques' number, Crouse integral, intima-media thickness and serum levels of CD40L and hs-CRP as compared with that before treatment, also with those in the control group after treatment (P<0.05 or P<0.01). No adverse reaction was found in the treatment course. Conclusion QQG has certain stabilizing action on CVAP in patients with CHD.