国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2010年
2期
151-156
,共6页
脑损伤%脊髓损伤%神经胶质%体内稳态%星形胶质细胞%小胶质细胞%少突胶质细胞%神经再生%神经元可塑性%神经元
腦損傷%脊髓損傷%神經膠質%體內穩態%星形膠質細胞%小膠質細胞%少突膠質細胞%神經再生%神經元可塑性%神經元
뇌손상%척수손상%신경효질%체내은태%성형효질세포%소효질세포%소돌효질세포%신경재생%신경원가소성%신경원
Brain injuries%Spinal cord injuries%Neuroglia%Homeostasis%Astrocytes%Microglia%Oligodendroglia%Nerve regeneration%Neuronal plasticity%Neurons
中枢神经系统(central mervous system,CNS)损伤包括腩损伤和脊髓损伤,致残率和病死率较高.因此,CNS损伤修复一直是神经科学领域的一个研究重点和热点.成年哺乳动物神经元的内在再生能力有限是CNS损伤后再生困难的原因之一,但更为重要的原因是损伤局部抑制性胶质微环境的形成.文章就胶质微环境内星形胶质细胞、小胶质细胞、少突胶质细胞等各类组成细胞在CNS损伤修复中的作用做了综述.
中樞神經繫統(central mervous system,CNS)損傷包括腩損傷和脊髓損傷,緻殘率和病死率較高.因此,CNS損傷脩複一直是神經科學領域的一箇研究重點和熱點.成年哺乳動物神經元的內在再生能力有限是CNS損傷後再生睏難的原因之一,但更為重要的原因是損傷跼部抑製性膠質微環境的形成.文章就膠質微環境內星形膠質細胞、小膠質細胞、少突膠質細胞等各類組成細胞在CNS損傷脩複中的作用做瞭綜述.
중추신경계통(central mervous system,CNS)손상포괄남손상화척수손상,치잔솔화병사솔교고.인차,CNS손상수복일직시신경과학영역적일개연구중점화열점.성년포유동물신경원적내재재생능력유한시CNS손상후재생곤난적원인지일,단경위중요적원인시손상국부억제성효질미배경적형성.문장취효질미배경내성형효질세포、소효질세포、소돌효질세포등각류조성세포재CNS손상수복중적작용주료종술.
Central nervous system (CNS) injury, including brain injury and spinal cord injury, has higher disability and mortality. Therefore, CNS injury repair has been a research emphasis and focus in the field of neuroscience. The limited neurons intrinsic regenerative capacity in adult mammalians is one of the reasons of regeneration difficulties after CNS injury. However, the more important reason is the formation of inhibitive glial microenvironment at the local lesion sites. This article reviews the roles of all types of cells, such as astrocyte, microglia, taxi oligodendroglia in gtial microenvironment in CNS injury repair.
