中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
4期
17-19
,共3页
胰岛素%血红蛋白A,糖基化%胰岛素类似物
胰島素%血紅蛋白A,糖基化%胰島素類似物
이도소%혈홍단백A,당기화%이도소유사물
Insulin%Hemoglobin A,glycosylated%Insulin analog
目的 探讨人胰岛素类似物与人胰岛素减低糖化血红蛋白(HbA1c)水平的差异.方法 随机抽取120例2型糖尿病患者,按住院号奇偶数分为人胰岛素类似物组和人胰岛素组,每组60例,比较两组在患病结局、血糖控制、HbA1c之间的差异.结果 人胰岛素类似物组治疗良好率(83.3%,50/60)与人胰岛素组治疗良好率(86.7%,52/60)比较差异无统计学意义(P＞0.05).治疗前两组空腹血糖和餐后2 h血糖比较差异无统计学意义(P＞0.05),治疗2周后两组比较差异有统计学意义(P＜0.05);两组内治疗前与治疗2周后空腹血糖和餐后2h血糖比较差异均有统计学意义(P＜0.05).治疗前两组HbA1c比较差异无统计学意义(P＞0.05),治疗3个月后两组比较差异有统计学意义(P＜0.05);两组内治疗前与治疗3个月后HbA1c比较差异均有统计学意义(P＜0.05).结论 人胰岛素类似物与人胰岛素在控制糖尿病患者血糖和HbA1c方面效果均较好,但人胰岛素类似物优于人胰岛素.
目的 探討人胰島素類似物與人胰島素減低糖化血紅蛋白(HbA1c)水平的差異.方法 隨機抽取120例2型糖尿病患者,按住院號奇偶數分為人胰島素類似物組和人胰島素組,每組60例,比較兩組在患病結跼、血糖控製、HbA1c之間的差異.結果 人胰島素類似物組治療良好率(83.3%,50/60)與人胰島素組治療良好率(86.7%,52/60)比較差異無統計學意義(P＞0.05).治療前兩組空腹血糖和餐後2 h血糖比較差異無統計學意義(P＞0.05),治療2週後兩組比較差異有統計學意義(P＜0.05);兩組內治療前與治療2週後空腹血糖和餐後2h血糖比較差異均有統計學意義(P＜0.05).治療前兩組HbA1c比較差異無統計學意義(P＞0.05),治療3箇月後兩組比較差異有統計學意義(P＜0.05);兩組內治療前與治療3箇月後HbA1c比較差異均有統計學意義(P＜0.05).結論 人胰島素類似物與人胰島素在控製糖尿病患者血糖和HbA1c方麵效果均較好,但人胰島素類似物優于人胰島素.
목적 탐토인이도소유사물여인이도소감저당화혈홍단백(HbA1c)수평적차이.방법 수궤추취120례2형당뇨병환자,안주원호기우수분위인이도소유사물조화인이도소조,매조60례,비교량조재환병결국、혈당공제、HbA1c지간적차이.결과 인이도소유사물조치료량호솔(83.3%,50/60)여인이도소조치료량호솔(86.7%,52/60)비교차이무통계학의의(P＞0.05).치료전량조공복혈당화찬후2 h혈당비교차이무통계학의의(P＞0.05),치료2주후량조비교차이유통계학의의(P＜0.05);량조내치료전여치료2주후공복혈당화찬후2h혈당비교차이균유통계학의의(P＜0.05).치료전량조HbA1c비교차이무통계학의의(P＞0.05),치료3개월후량조비교차이유통계학의의(P＜0.05);량조내치료전여치료3개월후HbA1c비교차이균유통계학의의(P＜0.05).결론 인이도소유사물여인이도소재공제당뇨병환자혈당화HbA1c방면효과균교호,단인이도소유사물우우인이도소.
Objective To compare the level of glycosylated hemoglobin (HbA1c) in patients with diabetes treated with actrapid monotard analog or actrapid monotard. Methods One hundred and twenty patients with type 2 diabetes were divided into actrapid monotard analog group and actrapid monotard group with 60 cases in each by admission number. Fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPBG), HbA1c were obtained and analyzed. Results The overall cure rate were similar between actrapid monotard analog group and actrapid monotard group (83.3%, 50/60 vs. 86.7%, 52/60, P ＞ 0.05 ). There was no significant difference in FBG, 2hPBG before treatment between two groups (P ＞ 0.05),but there was significant difference at 2 weeks after treatment between two groups (P ＜ 0.05 ) . There was no significant difference in HbA1c before treatment between two groups (P＞ 0.05 ) ,but there was significant difference at 3 months after treatment between two groups (P ＜ 0.05 ). FBG, 2hPBG, HbA1c after treatment were improved compared with before treatment in two groups (P ＜ 0.05 ). Conclusion Actrapid monotard analog provides better blood glucose control compare with actrapid monotard while providing the convenience of injecting immediately before meals.
