CAJ | 학술논문

目的探讨高压氧(HBO)治疗对急性心肌梗死(AMI)大鼠模型梗死面积及左室功能的影响.方法 50只健康雄性SD大白鼠,分为左冠状动脉未结扎组12只,另38只以手术方式结扎左冠状动脉,术后6 h 5只大鼠死亡,存活的33只再分为HBO对照组(n=16)和HBO组(n=17),HBO组心肌梗死后应用HBO治疗,7 d后测量心肌梗死面积、左心室收缩压和舒张压差(LVEDP)及左心室内压最大上升和下降速率(±dp/dtmax)的变化.结果 HBO组与HBO对照组相比,心肌梗死面积明显减小(P<0.05),左室功能明显好转(P<0.05).结论及早应用HBO治疗可以明显减少AMI大鼠模型心肌坏死面积,并且可以改善左室的收缩及舒张功能.
목적 탐토고압양(HBO)치료대급성심기경사(AMI)대서모형경사면적급좌실공능적영향.방법 50지건강웅성SD대백서,분위좌관상동맥미결찰조12지,령38지이수술방식결찰좌관상동맥,술후6 h 5지대서사망,존활적33지재분위HBO대조조(n=16)화HBO조(n=17),HBO조심기경사후응용HBO치료,7 d후측량심기경사면적、좌심실수축압화서장압차(LVEDP)급좌심실내압최대상승화하강속솔(±dp/dtmax)적변화.결과 HBO조여HBO대조조상비,심기경사면적명현감소(P<0.05),좌실공능명현호전(P<0.05).결론 급조응용HBO치료가이명현감소AMI대서모형심기배사면적,병차가이개선좌실적수축급서장공능.
Objective To investigate effect of hyperbaric oxygen treatment on infarct size of acute myocardial infarction and on the function of left ventricle in rats. Methods An acute myocardial infarction model was developed by using 50 male SD rats, which were randomly divided into 3 groups: the sham group(12 rats), the acute myocardial infarction group (AMI) (16 rats) and the HBO group(17 rats). Hyperbaric oxygen treatment was applied to the HBO group for a succession of 7 days. Infarct sizes, differences between systolic and diastolic pressures of the three groups and changes in cardiac hemodynamics (± dp/dtmax) were measured 7 days after treatment. Results When compared with that of the AMI group, infarct size and left ventricle function of the HBO group improved significantly (P < 0. 05). Conclusions Early administration of HBO could significantly reduce infarct size and improve left ventricle function of rats with AMI.