CAJ | 학술논문

目的了解沈阳地区湿疹皮炎患者接触性变应原的分布及其特点.方法收集2008年3～11月诊断为湿疹皮炎患者,应用斑贴试验分析患者接触性变应原.结果 89例检测患者中,25例斑贴试验呈现阳性反应,阳性率为28.09％.对1种变应原致敏阳性者21例(占23.60％),对2种变应原致敏阳性者3例(占3.37％),对3种变应原阳性者0例(占0.00％),对4种及4种以上变应原阳性者1例(占1.12％),阴性者30例(占33.71％).列前4位的常见变应原致敏依次为:硫酸镍、对苯二胺、硫柳汞、芳香混合物.男女斑贴试验阳性率经统计学处理,差异无统计学意义(P＞0.05).男性患者中阳性率居前3位的变应原是硫酸镍、硫柳汞、甲醛.女性患者中列前3位分别为对苯二胺、硫酸镍、芳香混合物(后2者并列第2).男性患者中硫酸镍、硫柳汞的阳性检出率比女性明显增高,差异有统计学意义(P＜0.05).中青年组与中老年组阳性率差异无统计学意义(P＞0.05).结论斑贴试验有助于明确湿疹皮炎患者的接触性变应原,为疾病的预防及治疗有一定的提示及参考意义.
목적 료해침양지구습진피염환자접촉성변응원적분포급기특점.방법 수집2008년3～11월진단위습진피염환자,응용반첩시험분석환자접촉성변응원.결과 89례검측환자중,25례반첩시험정현양성반응,양성솔위28.09％.대1충변응원치민양성자21례(점23.60％),대2충변응원치민양성자3례(점3.37％),대3충변응원양성자0례(점0.00％),대4충급4충이상변응원양성자1례(점1.12％),음성자30례(점33.71％).렬전4위적상견변응원치민의차위:류산얼、대분이알、류류홍、방향혼합물.남녀반첩시험양성솔경통계학처리,차이무통계학의의(P＞0.05).남성환자중양성솔거전3위적변응원시류산얼、류류홍、갑철.녀성환자중렬전3위분별위대분이알、류산얼、방향혼합물(후2자병렬제2).남성환자중류산얼、류류홍적양성검출솔비녀성명현증고,차이유통계학의의(P＜0.05).중청년조여중노년조양성솔차이무통계학의의(P＞0.05).결론 반첩시험유조우명학습진피염환자적접촉성변응원,위질병적예방급치료유일정적제시급삼고의의.
Objective To explore the distribution and their characteristics of contact allergens in patients with eczema and dermatitis in Shenyang.Methods Patients who were clinically diagnosed as eczema or dermatitis in the Department of Dermatology,No.1 Affiliated Hospital of China Medical Univer sity between March 2008 to November 2008 were enrolled in this study.They were tested with a standardized screening antigen kit on their back or inner part of upper arm,and interpreted 72 hours after patching.Results Patch test was completed in 89 patients and 25 (28.09 ％) showed at least one positive allergen of 20 standardized screening antigens.Twenty-one patients had one positive allergen (23.60 ％) while 3 patients had two positive antigens (3.37 ％).No one showed three positive antigens,and four or more than 4 antigens were positive in 1 patient (1.12 ％).All antigens were negative in 30 patients (33.71％).The top four allergens were nickel sulfate,para-phenylenediamine,thimerosal,and fragrant mix in all 89 patients.There was no statistical difference between male group and female group.The top three allergens were nickel sulfate,thimerosal,formaldehyde in male group while para-phenylenediamine,nickel sulfate,fragrant mix were top three in female group (the last two were same).The positive rate of nickel sulfate and thimerosal was obviously higher in male group than female group,and the difference was statistically significant.No statistical significance of positive rate occurred between the youth group and the old group.Conclusions Patchtest is helpful in identifying the property of contact allergens in para eczema and dermatitis,and it is of significance in clinical prevention and treatment of such diseases.