中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
10期
27-28
,共2页
慢性阻塞性肺疾病%干扰素-γ%白细胞介素-6%白细胞介素-8%肿瘤坏死因子-α
慢性阻塞性肺疾病%榦擾素-γ%白細胞介素-6%白細胞介素-8%腫瘤壞死因子-α
만성조새성폐질병%간우소-γ%백세포개소-6%백세포개소-8%종류배사인자-α
Chronic obstructive pulmonary disease%Interferon-γ%Interleukin-6%Interleukin-8%Tumor necrosis factor-α
目的 探讨检测慢性阻塞性肺疾病(COPD)患者血清中干扰素-γ(IFN-γ)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)的水平变化及意义.方法 选择100例COPD患者作为研究对象,其中急性加重期50例,稳定期50例,另外选择30例健康体检者作为正常对照组,采用酶联免疫法分别检测血清中IFN-γ、1L-6、IL-8和TNF-α的水平.结果 COPD急性加重期和缓解期患者血清IFN-γ、IL-6、IL-8和TNF-α的水平明显高于健康对照组(P＜0.05),COPD急性加重期IFN-γ、IL-6、IL-8和TNF-α的水平明显高于缓解期患者(P＜0.05).结论 IFN-γ 、IL-6、IL-8和TNF-α是COPD的病理生理过程中重要的炎性介质,在COPD的发生及发展过程中可能起重要作用.检测IFN-γ、IL-6、IL-8和TNF-α有助于COPD患者病情及预后的判断.
目的 探討檢測慢性阻塞性肺疾病(COPD)患者血清中榦擾素-γ(IFN-γ)、白細胞介素-6(IL-6)、白細胞介素-8(IL-8)和腫瘤壞死因子-α(TNF-α)的水平變化及意義.方法 選擇100例COPD患者作為研究對象,其中急性加重期50例,穩定期50例,另外選擇30例健康體檢者作為正常對照組,採用酶聯免疫法分彆檢測血清中IFN-γ、1L-6、IL-8和TNF-α的水平.結果 COPD急性加重期和緩解期患者血清IFN-γ、IL-6、IL-8和TNF-α的水平明顯高于健康對照組(P＜0.05),COPD急性加重期IFN-γ、IL-6、IL-8和TNF-α的水平明顯高于緩解期患者(P＜0.05).結論 IFN-γ 、IL-6、IL-8和TNF-α是COPD的病理生理過程中重要的炎性介質,在COPD的髮生及髮展過程中可能起重要作用.檢測IFN-γ、IL-6、IL-8和TNF-α有助于COPD患者病情及預後的判斷.
목적 탐토검측만성조새성폐질병(COPD)환자혈청중간우소-γ(IFN-γ)、백세포개소-6(IL-6)、백세포개소-8(IL-8)화종류배사인자-α(TNF-α)적수평변화급의의.방법 선택100례COPD환자작위연구대상,기중급성가중기50례,은정기50례,령외선택30례건강체검자작위정상대조조,채용매련면역법분별검측혈청중IFN-γ、1L-6、IL-8화TNF-α적수평.결과 COPD급성가중기화완해기환자혈청IFN-γ、IL-6、IL-8화TNF-α적수평명현고우건강대조조(P＜0.05),COPD급성가중기IFN-γ、IL-6、IL-8화TNF-α적수평명현고우완해기환자(P＜0.05).결론 IFN-γ 、IL-6、IL-8화TNF-α시COPD적병리생리과정중중요적염성개질,재COPD적발생급발전과정중가능기중요작용.검측IFN-γ、IL-6、IL-8화TNF-α유조우COPD환자병정급예후적판단.
Objective To investigate the changes and clinical significance of serum levels of interferon-γ( IFN-γ),interleukin-6 ( IL-6 ),IL-8 and tumor necrosis factor-α (TNF-α) in patients with chronic obstructive pulmonary disease (COPD).Methods The serum was sampled and prepared from 100 cases of COPD (exacerbation group 50 cases,remission group 50 cases)patients and 30 healthy persons.The serum levels of IFN-γ,IL-6,IL-8 and TNF-αt were detected by ELISA.Results Serum levels of IFN-γ,IL-6,IL-8 and TNF-α in the cases of COPD with stable stage and the period of AECOPD were higher than those in the healthy cases (P ＜ 0.05).Serum levels of IFN-γ,IL-6,IL-8 and TNF-α in the period of AECOPD were higher than those in the cases of COPD with stable stage ( P ＜ 0.05 ).Conclusions IFN-γ,IL-6,IL-8 and TNF-α participated in the pathogenesis of COPD.Monitoring the changes of their serum levels is helpful for the management of the disease,and probably can be a prognostic factor of COPD.
