中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
19期
26-27
,共2页
耐药性肺结核%病因%左旋氧氟沙星%治疗作用
耐藥性肺結覈%病因%左鏇氧氟沙星%治療作用
내약성폐결핵%병인%좌선양불사성%치료작용
Drug-resistant pulmonary%Tuberculosis%Cause of disease%Levofloxacin%Therapeutic effects
目的 总结分析耐药肺结核的原因及左旋氧氟沙星在耐药肺结核治疗中的作用.方法 对142例耐药肺结核患者的临床资料进行回顾性分析,并探讨左旋氧氟沙星在耐药肺结核治疗中的作用.结果 142例耐药肺结核患者单耐异胭肼26例,单耐利福平12例,同时耐异烟肼、利福平34例,同时耐异烟肼、链霉素、乙胺丁醇12例,同时耐利福平、链霉素10例,同时耐异烟肼、利福平、乙胺丁醇14例,同时耐异烟肼、利福平、链霉素34例.其原因为方案不合理56例,自行停药32例,由药物引起的不良反应而停药20例,医源性因素34例.合左旋氧氟沙星治疗方案症状消失62例,症状明显吸收58例,痰菌阴转率65%,两者相比差异有统计学意义(P<0.05).结论 耐药肺结核的原因有医生、患者和药物三方面的因素,左旋氧氟沙星在治疗耐药肺结核中有重要作用.
目的 總結分析耐藥肺結覈的原因及左鏇氧氟沙星在耐藥肺結覈治療中的作用.方法 對142例耐藥肺結覈患者的臨床資料進行迴顧性分析,併探討左鏇氧氟沙星在耐藥肺結覈治療中的作用.結果 142例耐藥肺結覈患者單耐異胭肼26例,單耐利福平12例,同時耐異煙肼、利福平34例,同時耐異煙肼、鏈黴素、乙胺丁醇12例,同時耐利福平、鏈黴素10例,同時耐異煙肼、利福平、乙胺丁醇14例,同時耐異煙肼、利福平、鏈黴素34例.其原因為方案不閤理56例,自行停藥32例,由藥物引起的不良反應而停藥20例,醫源性因素34例.閤左鏇氧氟沙星治療方案癥狀消失62例,癥狀明顯吸收58例,痰菌陰轉率65%,兩者相比差異有統計學意義(P<0.05).結論 耐藥肺結覈的原因有醫生、患者和藥物三方麵的因素,左鏇氧氟沙星在治療耐藥肺結覈中有重要作用.
목적 총결분석내약폐결핵적원인급좌선양불사성재내약폐결핵치료중적작용.방법 대142례내약폐결핵환자적림상자료진행회고성분석,병탐토좌선양불사성재내약폐결핵치료중적작용.결과 142례내약폐결핵환자단내이연정26례,단내리복평12례,동시내이연정、리복평34례,동시내이연정、련매소、을알정순12례,동시내리복평、련매소10례,동시내이연정、리복평、을알정순14례,동시내이연정、리복평、련매소34례.기원인위방안불합리56례,자행정약32례,유약물인기적불량반응이정약20례,의원성인소34례.합좌선양불사성치료방안증상소실62례,증상명현흡수58례,담균음전솔65%,량자상비차이유통계학의의(P<0.05).결론 내약폐결핵적원인유의생、환자화약물삼방면적인소,좌선양불사성재치료내약폐결핵중유중요작용.
Objective To analyse the cause of drug - resistant tuberculosis and the effects of levofloxacin on the treatment of drug - resistant pulmonary tuberculosis. Methods One hundred and forty - two cases with drug - resistant tuber-culosis and the treat effects of levofloxacin in drug - resistant tuberculosis were retrospectively analyzed. Results One hun-dred and forty- two cases with drug- resistant tuberculosis were as follows: INH- resistant in 26, RFP- resistant in 12,re-sistant to RFP and SM in 10,resistant to INH and RFP in 34,resistant to INH,SM and EMB in 12, resistant to INH,RFP and EMB in 14, resistant to INH, RFP and SM in 34. The reasons for drug -resistant in 142 cases were as follows: 56 cases were due to improper treatment, 32 cases were due to stopping medical treatment,20 cases were due to the side -effect of drugs,and 34 cases were due to iatrogenic reason. The therapeutic group which contain levofloxacin,the symptoms of 62 cases were disappeared; the tuberculosis focus were ab-sorbed obviously in 58 cases;the rate of negative in sputum reached 65%. It had significantly different compare without con-tain levofloxacin(P <0.05). Conclusions The doctor,patient and drug factors play an important roles in producing drug -resistanting,and the levofloxacin plays an important role on the treatment of drug - resistant pulmonary tuberculosis.
