CAJ | 학술논문

从海洋真菌根霉2-PDA-61中共发现6个已知化合物,其中包括2个细胞毒活性的环五肽(1和2)和4个苯的衍生物(3-6).通过波谱学数据分析和与已知化合物数据比较,这些化合物分别被鉴定为malformin C(1)、malfonnin A1(2)、2,5-二羟基苯乙酸甲酯(3)、对羟基苯乙醇(4)、对甲基苯乙醇(5)和对苯二甲醚(6).化合物1和2对P388细胞系表现出中等强度的细胞毒活性,IC50值分别为1.8 μM和4.2 μM.
종해양진균근매2-PDA-61중공발현6개이지화합물,기중포괄2개세포독활성적배오태(1화2)화4개분적연생물(3-6).통과파보학수거분석화여이지화합물수거비교,저사화합물분별피감정위malformin C(1)、malfonnin A1(2)、2,5-이간기분을산갑지(3)、대간기분을순(4)、대갑기분을순(5)화대분이갑미(6).화합물1화2대P388세포계표현출중등강도적세포독활성,IC50치분별위1.8 μM화4.2 μM.
Two cytotoxic cyclicpentapeptides(1 and 2)and four benzene derivatives(3-6)have been isolated from the marine-derived fungus Rhizopus sp.2-PDA-61.By spectral analysis and comparison the data with those of known compounds,they were identified as malformin C(1),malformin A1(2),2,5-dihydroxyphenylacetic acid methyl ester(3),P-hydroxy phenylethanol(4),p-methyl phenylethanol(5),and P-dimethoxybenzene(6),respectively.Moreover,compounds 1 and 2 displayed moderate cytotoxicities to P388 cell lines,and the IC50 values of them were 1.8 μM and 4.2 μM.