CAJ | 학술논문

目的探讨纤维多孔钛微球复合纳米锶磷灰石修复骨缺损的能力及其作用机制.方法 6月龄雄性SD大鼠24只,体重(545±22)g.在双侧股骨髁部使用慢速钻钻取直径2 mm贯通双侧皮质的冠状轴洞性骨缺损.以纤维多孔钛微球复合纳米锶磷灰石填充左侧骨缺损,以单纯纤维多孔钛微球填充右侧.术后1、2、4、8周分别处死6只大鼠行X线、组织学及骨组织形态计量学观察,并进行比较分析.结果影像学结果表明,两侧骨缺损修复效果均良好.组织学显示,纤维多孔钛微球允许骨长入,且左侧微球内新生骨多于右侧.骨组织形态计量学观察显示,随时间延长,左侧新生骨量逐渐增多,2、4、8周新生骨量存在差异,而4、8周时左侧与右侧的新生骨量比较,差异有统计学意义.结论纤维多孔钛微球具有良好的生物相容性及骨传导性,可作为骨缺损修复的支架材料;纳米锶磷灰石可增强纤维多孔钛微球修复骨缺损的能力.
목적 탐토섬유다공태미구복합납미송린회석수복골결손적능력급기작용궤제.방법 6월령웅성SD대서24지,체중(545±22)g.재쌍측고골과부사용만속찬찬취직경2 mm관통쌍측피질적관상축동성골결손.이섬유다공태미구복합납미송린회석전충좌측골결손,이단순섬유다공태미구전충우측.술후1、2、4、8주분별처사6지대서행X선、조직학급골조직형태계량학관찰,병진행비교분석.결과 영상학결과표명,량측골결손수복효과균량호.조직학현시,섬유다공태미구윤허골장입,차좌측미구내신생골다우우측.골조직형태계량학관찰현시,수시간연장,좌측신생골량축점증다,2、4、8주신생골량존재차이,이4、8주시좌측여우측적신생골량비교,차이유통계학의의.결론 섬유다공태미구구유량호적생물상용성급골전도성,가작위골결손수복적지가재료;납미송린회석가증강섬유다공태미구수복골결손적능력.
Objective To evaluate the effect of titanium fiber mesh microballoons combined with nano-Sr-HAP on repair of bone defects in vivo. Methods The experimental model was set up by creating drill defects in the bilateral femoral condyle of 24 SD rats [6 months, with the mean weight of (545±22 g)]. The left femoral defects were filled with titanium fiber mesh microballoons combined with nano-Sr-HAP, and the right with pure metal scaffolds. At the 1st, 2nd, 4th, and 8th week after surgery, the specimens were killed and taken the X-ray, histology, and histomorphology observation. The results were contrasted and ana-lyzed. Results X-ray observation showed that the bone defects in both sides were repaired. Histological re-sults showed that the titanium fiber mesh microballoons allowed the new bones growing inside, and more new bones in the left implants compared with those in the right sides. The results of histomorphometrical analysis confirmed that neo-bones in the left sides gradually increased as time passed. There were statistic differences in neo-bones at the 2nd, 4th, and 8th week, and the differences between the two sides were statistically sig-nificant at the 4th and 8th week. Conclusion As titanium fiber mesh microballoons used in this experiment have good biocompatibility and osteoconduction ability, they can be used as scaffold for bone defect repair; and Nano-Sr-HAP can enhance the repair ability of titanium fiber mesh.