CAJ | 학술논문

目的了解北京地区学龄儿童呼出气一氧化氮(eNO)水平.方法选择北京市11-18岁在校学生,采用过敏件疾病与哮喘的国际间对比研究调查问卷,通过填写问卷及现场体检对儿童进行分组(正常儿童组及曾患不同疾病儿童组),检测eNO水平、峰流速及过敏原.结果共筛选出正常儿童395名,男177名,女218名.不同性别正常儿童eNO差异无统计学意义(P均>0.05),但与其年龄呈正相关(男性P=0.008,女性P=0.05),在男性与其身高呈正相关(P=0.02).11～14岁、14～18岁正常儿童eNO几何均数(G)分别为11.22、14.13 ppb(ppb=10~9),其95%正常值范围分别为4.17～30.20 ppb、5.50～36.31 ppb.曾患哮喘/喘息(68例)和曾患过敏性鼻炎(96例)儿童eNO几何均数分别是19.05 ppb、14.79 ppb,与正常儿童差异有统计学意义(P分别为0.001、0.008).过敏原皮肤点刺检查阳性与阴性儿童eNO几何均数分别为16.98 ppb、11.75 ppb,两组间差异有统计学意义(P=0.001).结论北京地区11～18岁正常学龄儿童eNO随年龄波动于10.72～13.80ppb,与年龄、身高呈正相关,与性别无关.喘息性疾病、过敏性鼻炎患儿以及特应性个体eNO水平显著增加.
목적 료해북경지구학령인동호출기일양화담(eNO)수평.방법 선택북경시11-18세재교학생,채용과민건질병여효천적국제간대비연구조사문권,통과전사문권급현장체검대인동진행분조(정상인동조급증환불동질병인동조),검측eNO수평、봉류속급과민원.결과 공사선출정상인동395명,남177명,녀218명.불동성별정상인동eNO차이무통계학의의(P균>0.05),단여기년령정정상관(남성P=0.008,녀성P=0.05),재남성여기신고정정상관(P=0.02).11～14세、14～18세정상인동eNO궤하균수(G)분별위11.22、14.13 ppb(ppb=10~9),기95%정상치범위분별위4.17～30.20 ppb、5.50～36.31 ppb.증환효천/천식(68례)화증환과민성비염(96례)인동eNO궤하균수분별시19.05 ppb、14.79 ppb,여정상인동차이유통계학의의(P분별위0.001、0.008).과민원피부점자검사양성여음성인동eNO궤하균수분별위16.98 ppb、11.75 ppb,량조간차이유통계학의의(P=0.001).결론 북경지구11～18세정상학령인동eNO수년령파동우10.72～13.80ppb,여년령、신고정정상관,여성별무관.천식성질병、과민성비염환인이급특응성개체eNO수평현저증가.
Objective To learn the normal values of exhaled nitric oxide (eNO) in children. Method School children in Beijing from 11 to 18 years of age were included in the study. All the students were assigned into two groups: normal group and abnormal group (with allergic disease) according to the International Study of Asthma and Allergy in Childhood questionnaires, eNO, peak expiratory flow rate and sensitization were measured. Result Totally 395 students were screened out as normal subject (male: 177, female: 218). The eNO level was not significantly different between genders (P > 0.05 ), but was associated positively with age in both male and female group ( P = 0.008 and P = 0.05 respectively) and associated with height in male students ( P = 0.02 ). The geometric mean value of eNO was 11.22 ppb (parts per billion, ppb = 10~9) in children aged from 11 to 14 years and 14.13 ppb in children aged from 14 to 18 years,with 95% confidence interval 4.17 -30.20, 5.50 -36.31 ppb. The eNO level was significantly increased in children who "ever had asthma or wheezing" (n = 68 ), and children who "ever had rhinitis" (n=96) compared with normal subjects (P =0.001 and P =0.008). The geometric mean value of eNO was 16.98 ppb in children with positive skin prick test and was significantly increased as compared with children with negative skin prick test with eNO level at 11.75 ppb (P = 0.001 ). Conclusion eNO level varied between 10.72 ppb and 13.80 ppb in normal children 11-18 years of age, and was positively associated with age and height, but not with gender, eNO level increased significantly in children with wheezing and atopy.