CAJ | 학술논문

目的观察高甘油三酯血症对血管内皮功能的影响.方法对30例高甘油三酯血症患者和30例正常人,采用高分辨超声技术检测血流介导的和硝酸甘油介导的肱动脉舒张功能,并测定血浆内皮素和血脂.结果 1.高甘油三酯血症组血流介导的肱动脉舒张较正常组明显减弱[分别为(2.7±2.0)%和(15.0±8.0)%,P<0.001],而两组对硝酸甘油的血管舒张反应无显著性差异[分别为(15.0±5.0)%和(16.8±9.0)%,P>0.05].2.高甘油三酯血症组血浆内皮素水平显著高于正常组[分别为(106.22±19.16)μg/L和(72.37±14.06)μg/L,P<0.001].结论高甘油三酯血症患者内皮依赖性血管舒张功能明显受损.血管内皮功能失调可能是高甘油三酯血症致动脉粥样硬化的一个重要机制.
목적관찰고감유삼지혈증대혈관내피공능적영향.방법대30례고감유삼지혈증환자화30례정상인,채용고분변초성기술검측혈류개도적화초산감유개도적굉동맥서장공능,병측정혈장내피소화혈지.결과 1.고감유삼지혈증조혈류개도적굉동맥서장교정상조명현감약[분별위(2.7±2.0)%화(15.0±8.0)%,P<0.001],이량조대초산감유적혈관서장반응무현저성차이[분별위(15.0±5.0)%화(16.8±9.0)%,P>0.05].2.고감유삼지혈증조혈장내피소수평현저고우정상조[분별위(106.22±19.16)μg/L화(72.37±14.06)μg/L,P<0.001].결론고감유삼지혈증환자내피의뢰성혈관서장공능명현수손.혈관내피공능실조가능시고감유삼지혈증치동맥죽양경화적일개중요궤제.
Objective To investigate the effect of hypert riglyceridemia on vascular endothelial function. Methods With high-resolution ultrasound, flow and nitroglycerin-induced dilatation of the brachial artery were determined in thirty hypertriglyceridemic patients and thirty healthy subjects as controls. Serum lipid and plasma endothelin (ET) were determined. Results In patients with hypertriglyceridemia,flow-induced vasodilatation was much reduced compared with that in the control subjects[(2.7±2.0)% vs (15.0±8.0)%, P<0.001］.However, vasodilatation in response to nitroglycerin were similar in both groups［(15.0±5.0)% vs (16.8±9.0)%, P>0.05].Plasma ET level in the hypertriglyceridemic group was significantly higher than that in the control group［(106.22±19.16) μg/L vs (72.37±14.06) μg/L, P<0.001].Conclusion Endothelium-dependent vasodilatation was impaired in patients with hypertriglyceridemia.