CAJ | 학술논문

解聚素与金属蛋白酶10(ADAM10)是细胞膜上一种重要的调节分子.它通过调节性膜内蛋白水解(regulated intramembrane proteolysis),引起底物分子的胞外功能区的脱落,释放各种生长因子,或者调节细胞内的蛋白水解,进一步启动细胞内的信号转导途径.ADAM10通过这种方式参与了中枢神经系统的发育和生长、炎症反应以及肿瘤的形成和侵袭.本文仅就ADAM10的分子结构,4类主要的作用底物和发挥的功能作一简要介绍.
해취소여금속단백매10(ADAM10)시세포막상일충중요적조절분자.타통과조절성막내단백수해(regulated intramembrane proteolysis),인기저물분자적포외공능구적탈락,석방각충생장인자,혹자조절세포내적단백수해,진일보계동세포내적신호전도도경.ADAM10통과저충방식삼여료중추신경계통적발육화생장、염증반응이급종류적형성화침습.본문부취ADAM10적분자결구,4류주요적작용저물화발휘적공능작일간요개소.
A disintegrin and metalloprotease 10(ADAM10)is an important regulation molecule in the cell membrane. ADAM 10 are often implicated in ectodomain shedding, either to release e. g. growth factors or to initiate further intracellular signaling via regulated intramembrane proteolysis. By this way ADAM10 is involved in the development and growth of the central nervous system (CNS) 、 inflammation and the formation and infestation of cancer. In this paper, the structure and function and four major substrates of the ADAM 10 are briefly introduced.