CAJ | 학술논문

目的研究三氧化二砷对HepA小鼠肝癌生长、血管生成及侵袭与转移特性的影响.方法建立皮下种植肝癌小鼠模型,用药后观察小鼠肿瘤体积变化及抑瘤率;利用免疫组织化学观察移植瘤中血管内皮生长因子(VEGF),对移植瘤的微血管密度(MVD)进行计数.结果三氧化二砷对小鼠肝癌瘤体体积和抑瘤率均具有抑制作用;三氧化二砷能抑制肿瘤新生血管生成,降低VEGF的表达,并能降低肿瘤MVD,与未用药对照组相比差异均有统计学意义(P<0.05).结论三氧化二砷能缩小肿瘤体积、增加抑瘤率,并能降低VEGF的表达,减少微血管密度.
목적 연구삼양화이신대HepA소서간암생장、혈관생성급침습여전이특성적영향.방법 건립피하충식간암소서모형,용약후관찰소서종류체적변화급억류솔;이용면역조직화학관찰이식류중혈관내피생장인자(VEGF),대이식류적미혈관밀도(MVD)진행계수.결과 삼양화이신대소서간암류체체적화억류솔균구유억제작용;삼양화이신능억제종류신생혈관생성,강저VEGF적표체,병능강저종류MVD,여미용약대조조상비차이균유통계학의의(P<0.05).결론 삼양화이신능축소종류체적、증가억류솔,병능강저VEGF적표체,감소미혈관밀도.
Objective To study the effects of As_2O_3 on tumor model of hepatocarcinoma.Methods HepAgrafed hepatocarcinoma mouse model was established by subcutaneously injection of mouse hepatoma cells(1×10~6)into the oxter of mice.After treated by As_2O_3,the volume change of tumor and tumor inhibition rates were observed.The expression of vascular endothelial growth factor(VEGF) was detected by immunohistochemical and calculated the difference of MVD.Results The volume of tumor and the tumor inhibition rates were significantly decreased in As_2O_3 group compared with control group(P<0.05).The As_2O_3 could inhibit angiogenesis of xenograft tumor,depress expression of VEGF and decrease microvascular density(MVD).Conclusion As_2O_3 can inhibit the growth of tumor,inhibit the expression of VEGF and decrease MVD.