CAJ | 학술논문

目的探讨复发及未控的卵巢恶性生殖细胞肿瘤的治疗方法及预后.方法回顾性分析北京协和医院自1983-2008年收治的复发及未控的卵巢恶性乍殖细胞肿瘤患者17例,总结其初次治疗情况(手术和化疗)及未控或复发后的治疗情况及预后.结果 17例患者均接受了肿瘤切除手术,其中只有4例初次手术时可以明确分期情况.除1例在本院进行初次治疗的患者接受了规范化疗(为初治后复发患者)外.其余l6例在外院进行治疗的患者均未经规范的化疗(均为初治后未控的患者),结果在初次手术后1～8个月再次发现肿瘤生长.有15例患者接受了再次肿瘤切除手术,术后进行了及时规范的化疗.8例患者治疗成功,随诊期间未见肿瘸复发;5例因各种原因放弃治疗;4例失访.结论卵巢恶性生殖细胞肿瘤规范的初次治疗很重要,即使对于复发及未控的肿瘤,仍应积极进行肿瘤细胞减灭术,术后采用规范的化疗,仍有使肿瘤治愈的可能.
목적 탐토복발급미공적란소악성생식세포종류적치료방법급예후.방법 회고성분석북경협화의원자1983-2008년수치적복발급미공적란소악성사식세포종류환자17례,총결기초차치료정황(수술화화료)급미공혹복발후적치료정황급예후.결과 17례환자균접수료종류절제수술,기중지유4례초차수술시가이명학분기정황.제1례재본원진행초차치료적환자접수료규범화료(위초치후복발환자)외.기여l6례재외원진행치료적환자균미경규범적화료(균위초치후미공적환자),결과재초차수술후1～8개월재차발현종류생장.유15례환자접수료재차종류절제수술,술후진행료급시규범적화료.8례환자치료성공,수진기간미견종가복발;5례인각충원인방기치료;4례실방.결론 란소악성생식세포종류규범적초차치료흔중요,즉사대우복발급미공적종류,잉응적겁진행종류세포감멸술,술후채용규범적화료,잉유사종류치유적가능.
Objective To study the clinical characteristic, the optimal treatments and the prognosis for the recurrence and failure of primary treatment in malignant ovarian germ cell tumors (MOGCT).Methods The clinical data of 17 recurrent and failure of primary treatment in MOGCT cases treated in Pecking Union Medical College Hospital from January 1983 to May 2008 were analyzed retrospectively to evaluate failure of primary treatment and second treatment. Results Only the 4 eases of recurrent and failure of primary treatment of MOGCT were underwent comprehensive surgical staging. After primary surgery in 1 -8 months, 16 cases received the non-standard chemotherapy were found the lesion again. The secondary debulking surgery was done for the 15 cases and also received the standard chemotherapy. Among of them, 8 cases were survival during follow up, 5 cases gave up the treatment and 4 patients were lost following up during the treatment. Conclusions The standard primary treatment is the most important for the MOGCT. Even for the recurrence and failure of primary treatment of MOGCT, the satisfied cytoreduetive surgery plus the standard chemotherapy also show the significant impact on the prognosis.