CAJ | 학술논문

目的研制小儿罗叶泵用于小儿心室辅助,评估它在动物实验中的初步应用.方法 14头山羊,体质量(14.8±1.4)kg,随机分为小儿罗叶泵组(L-Y组,n=7)和柏林心脏Excor泵组(BH组,n=7).分别在降主动脉近段和左房插F14动脉插管和F22静脉引流管,接心室辅助泵的出入口,使用Medos驱动装置控制泵的参数.分别于心室辅助前、心室辅助2、4、6 h,记录控制参数、平均动脉压、心率的变化,检测血小板颗粒膜蛋白、游离血红蛋白以及肝肾功能指标.结果 L-Y组的正压参数(103±4)mm Hg,低于BH组的(165±22)mm Hg(P＜0.05),负压参数差异无统计学意义(P＞0.05).L-Y组流量为(1.20±0.20)L/min,显著高于BH组(0.94±0.22)L/min(P＜0.05).心室辅助过程中两组动物平均动脉压和心率差异无统计学意义(P＞0.05).两组血小板颗粒膜蛋白、游离血红蛋白含量没有明显变化.尿素氮(BUN)、肌酐(Cr)、总胆红素(TIB)、门冬氨酸转移酶(AST)、乳酸(Lac)含量在两组之间的差异无统计学意义(P＞0.05).结论小儿罗叶泵同柏林心脏Excor泵一样对血压和心率的影响较小,对血液及肝肾功能的破坏较少,在控制参数方面优于柏林心脏Excor泵.
목적 연제소인라협빙용우소인심실보조,평고타재동물실험중적초보응용.방법 14두산양,체질량(14.8±1.4)kg,수궤분위소인라협빙조(L-Y조,n=7)화백림심장Excor빙조(BH조,n=7).분별재강주동맥근단화좌방삽F14동맥삽관화F22정맥인류관,접심실보조빙적출입구,사용Medos구동장치공제빙적삼수.분별우심실보조전、심실보조2、4、6 h,기록공제삼수、평균동맥압、심솔적변화,검측혈소판과립막단백、유리혈홍단백이급간신공능지표.결과 L-Y조적정압삼수(103±4)mm Hg,저우BH조적(165±22)mm Hg(P＜0.05),부압삼수차이무통계학의의(P＞0.05).L-Y조류량위(1.20±0.20)L/min,현저고우BH조(0.94±0.22)L/min(P＜0.05).심실보조과정중량조동물평균동맥압화심솔차이무통계학의의(P＞0.05).량조혈소판과립막단백、유리혈홍단백함량몰유명현변화.뇨소담(BUN)、기항(Cr)、총담홍소(TIB)、문동안산전이매(AST)、유산(Lac)함량재량조지간적차이무통계학의의(P＞0.05).결론 소인라협빙동백림심장Excor빙일양대혈압화심솔적영향교소,대혈액급간신공능적파배교소,재공제삼수방면우우백림심장Excor빙.
Objective To evaluate the pediatric Luo-Ye pneumonic ventricular assist device (Luo-Ye pump) as a left ventricular assist device in the goat.Methods Fourteen goats weighing ( 14.8 ±1.4) kg were randomly individed into Luo-Ye pump group ( L-Y group,n = 7 ) and Berlin heart Excor group (BH group,n =7).Proximal descending aorta and left atrium were cannulated with Fl4 aortic cannula and F22 venous cannula respectively,and then cauunlas were connected with the pumps which were controlled by Medos drive unit.The mean blood pressure,heart rate and driving data were recorded during experiment.The serum platelet granulate membrane protein,free hemoglobin,hepatic and renal functions were assayed.Results The positive pressure of drive unit in L-Y group was less than that in BH group ( 103 ±4) mm Hg vs ( 165 ± 22) mm Hg,P＜O.05.The flow rate in L-Y group was higher than in BH group ( 1.20 ±0.20) L/min vs (0.94 ±0.22) L/min,P ＜0.05.The mean blood pressure and heart rate had no signiftcant changes during the experiment in two groups.There was no significant difference between two groups in the serum levels of platelet granulate membrane protein and free hemoglobin.No significant difference was found in the hepatic and renal functions between two groups.Conclusion The Luo-Ye pump demonstrated good initial hemodynamic performance and less injury to the blood,hepatic and renal function as Berlin heart Excor did.Furthermore,the driving date of Luo-Ye pump was better than that of Berlin heart Excor.