CAJ | 학술논문

以3,5-二甲氧基苯甲醛为原料,经Perkin反应生成α-取代-E-3,5-二甲氧基苯丙烯酸,然后脱去芳甲醚的甲基合成了三个新的α-取代-E-3,5-二羟基苯丙烯酸(4a～4c),其结构经~1H NMR,IR和MS确证.应用二甲苯致小鼠耳肿胀模型评价4的抗炎活性,结果表明它们均有抗炎活性.其中4b与阳性对照药阿司匹林相比,表现出显著性差异(P＜0.05).
이3,5-이갑양기분갑철위원료,경Perkin반응생성α-취대-E-3,5-이갑양기분병희산,연후탈거방갑미적갑기합성료삼개신적α-취대-E-3,5-이간기분병희산(4a～4c),기결구경~1H NMR,IR화MS학증.응용이갑분치소서이종창모형평개4적항염활성,결과표명타문균유항염활성.기중4b여양성대조약아사필림상비,표현출현저성차이(P＜0.05).
Three novel α-substituted-E-3,5-dihydroxyphenylpropenic acids(4a～4c) were synthesized from 3,5-dimethoxybenzaldehyde by Perkin reaction and O-demethylation,and their structures were characterized by ~1H NMR,IR and MS.The results of their anti-inflammatory activities against xylene-induced mice ear swelling showed that 4 exhibited certain anti-inflammatory activities.4b was more potent than aspirin(P＜0.05).