国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2010年
1期
65-68
,共4页
胰腺肿瘤%基因%基质金属蛋白酶类%细胞黏附分子%细胞因子类
胰腺腫瘤%基因%基質金屬蛋白酶類%細胞黏附分子%細胞因子類
이선종류%기인%기질금속단백매류%세포점부분자%세포인자류
Pancreatic neoplasms%Gene%Matrix metalloproteinases%Cell adhesion molecule%Cyto
浸润及转移是恶性肿瘤重要的生物学特征,是导致胰腺癌患者死亡的主要原因.目前研究发现,胰腺癌浸润及转移与一系列分子生物学改变密切相关,包括肿瘤转移相关基因异常、细胞外基质降解、肿瘤诱导血管生成、细胞黏附力及细胞因子改变等,但其确切机制仍不明确,仍需进一步深入研究.
浸潤及轉移是噁性腫瘤重要的生物學特徵,是導緻胰腺癌患者死亡的主要原因.目前研究髮現,胰腺癌浸潤及轉移與一繫列分子生物學改變密切相關,包括腫瘤轉移相關基因異常、細胞外基質降解、腫瘤誘導血管生成、細胞黏附力及細胞因子改變等,但其確切機製仍不明確,仍需進一步深入研究.
침윤급전이시악성종류중요적생물학특정,시도치이선암환자사망적주요원인.목전연구발현,이선암침윤급전이여일계렬분자생물학개변밀절상관,포괄종류전이상관기인이상、세포외기질강해、종류유도혈관생성、세포점부력급세포인자개변등,단기학절궤제잉불명학,잉수진일보심입연구.
Invasion and metastasis are the important biological features of malignant neoplasms,and are the main reasons for the death of patients with pancreatic neoplasms.Current researches find that invasion and metastasis of pancreatic neoplasms are closely related to series of molecular biological changes,including' abnormalities of tumor metastasis-related genes,degradation of extracellular matrix,tumor-induced angiogenesis,changes of the adhesion molecules and cytokines.However,the definite mechanism still remains unclear,and further researches are needed.
