CAJ | 학술논문

目的观察局部射频消融(RFA)联合细胞因子诱导的杀伤(CIK)细胞疗法治疗肝转移瘤的临床疗效. 方法 50例肝转移瘤患者分为RFA联合自体CIK细胞治疗23例(研究组)和单纯RFA治疗27例(对照组).于治疗前后检测血清肿瘤标志物水平及CD3+、CD4+、CD8+、CD4+/CD8+,局部复发率和Kamofsky评分变化. 结果联合治疗组局部复发率(13.04%)明显低于对照组(40.74%)(P<0.05);CD3+、CD4+、CIM+/CD8+均明显升高(P<0.01);肿瘤标志物下降者和Kamofsky评分升高者的比例均明显高于对照组(P<0.05). 结论 RFA联合CIK细胞治疗肝转移瘤有较好的临床疗效,明显提高患者的细胞免疫功能,且改善生活质量.
목적 관찰국부사빈소융(RFA)연합세포인자유도적살상(CIK)세포요법치료간전이류적림상료효. 방법 50례간전이류환자분위RFA연합자체CIK세포치료23례(연구조)화단순RFA치료27례(대조조).우치료전후검측혈청종류표지물수평급CD3+、CD4+、CD8+、CD4+/CD8+,국부복발솔화Kamofsky평분변화. 결과 연합치료조국부복발솔(13.04%)명현저우대조조(40.74%)(P<0.05);CD3+、CD4+、CIM+/CD8+균명현승고(P<0.01);종류표지물하강자화Kamofsky평분승고자적비례균명현고우대조조(P<0.05). 결론 RFA연합CIK세포치료간전이류유교호적림상료효,명현제고환자적세포면역공능,차개선생활질량.
Objective To observe the efficacy of cytokine induced killer (CIK) cells combined with radiofrequency ablmion (RFA) in treatment of liver metastases.Methods 23 patients were treated with CIK plus RFA, while 27 patients with RFA.Tumot markers and CD3+、CD4+、CD8+、CD4+/CD8+ were tested before and after treatment.Recurrence rate and Kamofsky score were also evaluated.Results The local recurrence rate in the study group was lower (13.04% vs.40.74%)(P<0.05),CD3+、CD4+、and CD4+/CD8+ were increased (P<0.01). The percentage of patients with decreased tumor markers and increased Kamofsky is higher (P<0.05);Conclusion The therapy of CIK combined with RFA has better efficacy on liver metastases,can enhance the cellular immune functions and improve the quality of life significantly.