中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2011年
5期
385-389
,共5页
金厅%王芳%胡伟汉%蔡修宇%葛楠%徐韬%林辉
金廳%王芳%鬍偉漢%蔡脩宇%葛楠%徐韜%林輝
금청%왕방%호위한%채수우%갈남%서도%림휘
乏氧诱导因子%血管内皮生长因子%免疫组织化学%下咽肿瘤%预后
乏氧誘導因子%血管內皮生長因子%免疫組織化學%下嚥腫瘤%預後
핍양유도인자%혈관내피생장인자%면역조직화학%하인종류%예후
Hypoxia-inducible factor lα%Vascular endothelial growth factor%Immunohistochemistry%Hypopharyngeal neoplasms%Prognosis
目的 分析乏氧诱导因子- 1α(HIF-1α)、血管内皮生长因子(VEGF)在下咽鳞癌及癌旁正常黏膜组织中的表达,探讨HIF-1α、VEGF在下咽鳞癌中表达的临床意义。方法 对62例患者应用免疫组化检测HIF-1α、VEGF的表达,并分析其与患者临床病理特征及预后关系。结果 HIF-1α、VEGF在鳞癌组织中的表达明显高于癌旁正常黏膜组织,分别为66.1％和26.3％(x2=18.02,P＜0.05)、67.7％和31.6％ (x2=19.22,P＜0.05)。HIF-1α表达强弱与T分期、N分期、TNM分期有关(x2 =4.23、5.83、9.94,P均＜0.05)。VEGF表达强弱与T分期、N分期、TNM分期、是否转移有关(x2 =5.62、7.38、15.75、4.29,P均＜0.05)。单因素分析显示HIF-1α、VEGF过表达者总生存率低于低表达者,分别为6.2％和84.2％(x2=29.25,P＜0.01)、6.1％和84.4％( x2=24.88,P＜0.01)。多因素分析显示HIF-1α与T分期是下咽癌患者的独立预后因素(x2=4.80、5.74,P均＜0.05)。结论HIF-1α、VEGF可作为评估下咽癌发展、转移及预后的参考指标之一,也为临床提供了靶向治疗方向。
目的 分析乏氧誘導因子- 1α(HIF-1α)、血管內皮生長因子(VEGF)在下嚥鱗癌及癌徬正常黏膜組織中的錶達,探討HIF-1α、VEGF在下嚥鱗癌中錶達的臨床意義。方法 對62例患者應用免疫組化檢測HIF-1α、VEGF的錶達,併分析其與患者臨床病理特徵及預後關繫。結果 HIF-1α、VEGF在鱗癌組織中的錶達明顯高于癌徬正常黏膜組織,分彆為66.1％和26.3％(x2=18.02,P＜0.05)、67.7％和31.6％ (x2=19.22,P＜0.05)。HIF-1α錶達彊弱與T分期、N分期、TNM分期有關(x2 =4.23、5.83、9.94,P均＜0.05)。VEGF錶達彊弱與T分期、N分期、TNM分期、是否轉移有關(x2 =5.62、7.38、15.75、4.29,P均＜0.05)。單因素分析顯示HIF-1α、VEGF過錶達者總生存率低于低錶達者,分彆為6.2％和84.2％(x2=29.25,P＜0.01)、6.1％和84.4％( x2=24.88,P＜0.01)。多因素分析顯示HIF-1α與T分期是下嚥癌患者的獨立預後因素(x2=4.80、5.74,P均＜0.05)。結論HIF-1α、VEGF可作為評估下嚥癌髮展、轉移及預後的參攷指標之一,也為臨床提供瞭靶嚮治療方嚮。
목적 분석핍양유도인자- 1α(HIF-1α)、혈관내피생장인자(VEGF)재하인린암급암방정상점막조직중적표체,탐토HIF-1α、VEGF재하인린암중표체적림상의의。방법 대62례환자응용면역조화검측HIF-1α、VEGF적표체,병분석기여환자림상병리특정급예후관계。결과 HIF-1α、VEGF재린암조직중적표체명현고우암방정상점막조직,분별위66.1％화26.3％(x2=18.02,P＜0.05)、67.7％화31.6％ (x2=19.22,P＜0.05)。HIF-1α표체강약여T분기、N분기、TNM분기유관(x2 =4.23、5.83、9.94,P균＜0.05)。VEGF표체강약여T분기、N분기、TNM분기、시부전이유관(x2 =5.62、7.38、15.75、4.29,P균＜0.05)。단인소분석현시HIF-1α、VEGF과표체자총생존솔저우저표체자,분별위6.2％화84.2％(x2=29.25,P＜0.01)、6.1％화84.4％( x2=24.88,P＜0.01)。다인소분석현시HIF-1α여T분기시하인암환자적독립예후인소(x2=4.80、5.74,P균＜0.05)。결론HIF-1α、VEGF가작위평고하인암발전、전이급예후적삼고지표지일,야위림상제공료파향치료방향。
Objective To examine the relationship between HIF-1αt and VEGF expression and the clinicopathological characteristics in hypopharyngeal squamous cell carcinoma. Methods The expression status of HIF-1α and VEGF were examined by immunohistochemistric method (IHC) in 62 tumor tissue and 19 paracancerous normal tissue. The relationships between the expression of HIF-1α and VEGF and clinicopathological characteristic were analyzed. Results HIF-1αt and VEGF expression were higher in hypopharyngeal carcinoma tissues than those in paracancerous normal tissues (66. 1％:26. 3％ ;x2 =18. 02,P ＜0. 05 ;67. 7％ : 31.6％ ; x2 =19.22, P ＜ 0. 05 ). The expression intensity of HIF-1 α was related to T stage, N stage and TNM stage ( x2 =4. 23,5.83,9.94,all P ＜0. 05). The expression intensity of VEGF was related to metastasis, T stage, N stage and TNM stage (x2 =5.62,7. 38,15.75,4. 29 ,all P ＜0. 05 ). There was minus relationship between overall survival and expression level of HIF-1 α and/or VEGF (x2 =29. 25, P＜0.01; x2 =24.88, P＜ 0.01 ). On multivariate analysis, HIF-1α expression and T stage were independent prognostic factors for overall survival (x2 =4.80,5.74, all P＜0. 05). Conclusions HIF-1α and VEGF may be considered as a parameter in evaluation of progression, metastasis and prognosis of hypopharyngeal carcinoma and also may be a direction of molecular target therapy.
