CAJ | 학술논문

目的研究前列地尔(前列腺素E1脂微球制剂)联合替米沙坦在治疗早期糖尿病肾病(DN)中对超敏C反应蛋白(hsCRP)及胱抑素(Cys C)水平的影响.方法收集本院门诊和住院病人71例早期DN患者,随机分为单纯前列地尔组24例,单纯替米沙坦组23例,联合用药组24例,进行12周临床观察治疗,分别比较三组血压、血糖、糖化血红蛋白(HbAl c)、尿微量白蛋白排泄率(UAER)、hsCRP及Cys C水平的变化.结果三组在治疗前各项指标无明显差异(P＞0.05);各组治疗12周后,UAER、hsCRP及Cys C指标都较治疗前均有明显好转(P＜0.01);而联合组的UAER、hsCRP 及Cys C较另两组改善更明显(P＜0.05).结论前列地尔联合替米沙坦治疗早期DN,能有效改善hsCRP、Cys C及减少UAER,并长期维持尿蛋白于低水平,有利于延缓甚至防止糖尿病肾病的发生和发展.
목적 연구전렬지이(전렬선소E1지미구제제)연합체미사탄재치료조기당뇨병신병(DN)중대초민C반응단백(hsCRP)급광억소(Cys C)수평적영향.방법 수집본원문진화주원병인71례조기DN환자,수궤분위단순전렬지이조24례,단순체미사탄조23례,연합용약조24례,진행12주림상관찰치료,분별비교삼조혈압、혈당、당화혈홍단백(HbAl c)、뇨미량백단백배설솔(UAER)、hsCRP급Cys C수평적변화.결과 삼조재치료전각항지표무명현차이(P＞0.05);각조치료12주후,UAER、hsCRP급Cys C지표도교치료전균유명현호전(P＜0.01);이연합조적UAER、hsCRP 급Cys C교령량조개선경명현(P＜0.05).결론 전렬지이연합체미사탄치료조기DN,능유효개선hsCRP、Cys C급감소UAER,병장기유지뇨단백우저수평,유리우연완심지방지당뇨병신병적발생화발전.
Objective To evaluate the The function of Alprostadil jointly for Telm isartan on High Sensitivity CRP and Cys C in patients with early diabetic nephropathy ( DN ).Methods Seventy-one patients with early DN were randomly assigned to the pure Alprostadil group(n=24)treated on Aiprostadi or the Telmisartan group(n=23)treated on telmisartan or the co-contractor group ( n=24 ) treated on Aiprostadi and Telmisartan.for 12 weeks. Changes before and after treatment in levels of blood pressure, serHm lipids, plasma glucose,HbAlc, urine albumin excretion rate ( UAER ), hsCRP and Cys-C were observed and compared between the three groups. Results The three groups showed similar levels of the indexes at baseline(P > 0.05). After 12 weeks of treatment, UAER, hsCRP, Cys C were significantly improved in three groups (P < 0.01). The combination group showed greater improvement in UAER, hsCRP and Cys C(P < 0.05)compared with the another controls. Conclusion Use of Alprostadil and telmisartan in the treatment of earlv diabetic nephr-opathy can decrease the levels of hsCRP, Cys C and microaibuminuria, And the long-term maintenance urine protein in the low level, is advantageous to the postponement even prevents diabetes nephropathy the occurrence and the development.