CAJ | 학술논문

目的观察VKH(Vogt-Koyanagi-Harada,VKH)综合征急性期与恢复期后极部视网膜功能的变化特点.方法对15例(30只眼)VKH综合征患者的急性期与恢复期进行mfERG测定,并与正常对照比较.结果急性期VKH综合征患者各环mfERGN1、P1波振幅均有降低、多数环峰时延长,变化有统计学意义(P<0.05);各区域振幅降低幅度不同,以中心凹1环处降低最为严重,P1波振幅仅有正常对照的25%,随离心度增加,振幅降低逐渐减轻;与急性期相比较,恢复期1～3环mfERG振幅提高(P<0.05),4～6环振幅改变无统计学意义.与正常对照相比较,恢复期各环振幅降低仍有统计学意义;发生渗出性视网膜脱离与否,两组患者之间mfERG差异无统计学意义(P>0.05).结论 VKH对后极部视网膜功能有严重影响,即使治疗后视力恢复较理想,视网膜功能仍有较大程度损害.黄斑是治疗前后功能变化较大的部位.
목적 관찰VKH(Vogt-Koyanagi-Harada,VKH)종합정급성기여회복기후겁부시망막공능적변화특점.방법 대15례(30지안)VKH종합정환자적급성기여회복기진행mfERG측정,병여정상대조비교.결과 급성기VKH종합정환자각배mfERGN1、P1파진폭균유강저、다수배봉시연장,변화유통계학의의(P<0.05);각구역진폭강저폭도불동,이중심요1배처강저최위엄중,P1파진폭부유정상대조적25%,수리심도증가,진폭강저축점감경;여급성기상비교,회복기1～3배mfERG진폭제고(P<0.05),4～6배진폭개변무통계학의의.여정상대조상비교,회복기각배진폭강저잉유통계학의의;발생삼출성시망막탈리여부,량조환자지간mfERG차이무통계학의의(P>0.05).결론 VKH대후겁부시망막공능유엄중영향,즉사치료후시력회복교이상,시망막공능잉유교대정도손해.황반시치료전후공능변화교대적부위.
Objective To observe the features of posterior retinal function in acute and recovery stages of VKH syndrome. Methods The mfERG was recorded in 15 VKH cases (30 eyes) both in acute and recovery stage, the results were also compared with normal control. Results In the acute stage, the amplitudes ofN1, P1 waves were significantly decreased, as well as the implicit times were significantly prolonged in all the 6 rings, except implicit times of P1 in 5 and 6 ring (P<0.05). These abnormalities had a regional difference, the most decreased part was fovea (1 ring). The amplitude of P1 wave at 1 ring was only 25% of normal. There was a tendency that the abnormal degree of mfERG was lessened as the acentric degree increased. In the recovery stage, the amplitudes inside the 3 rings were remarkably increased (P<0.05), no significant amplitude changed as compared with acute stage outside the 3 rings. In this stage, the amplitudes of all rings were still remained great difference with normal control. There were no significant differences of mfERG date in acute VKH with or without exudative retinal detachment (P>0.05). Conclusions VKH has a serious damage to the posterior retinal function, even satisfied visual acuities acquired after proper and prompt treatment. Macula is the part with great functional variation before and after medication.