CAJ | 학술논문

目的观察老年冠心病(CAD)患者血管内皮舒张功能、动脉硬化的状况及与冠状动脉病变的相关性.方法选择经冠状动脉造影确诊为CAD的患者90例(CAD组),冠状动脉造影证实无冠状动脉狭窄并无其他疾病史的患者30例为对照组,采用二维超声检测肱动脉内皮依赖性和非依赖性舒张功能及动脉内膜的变化,应用二维彩色多普勒超声检查颈动脉、股动脉,观察管腔、管径、内膜及有无斑块、血流变化、血流频谱形态及性质.动脉粥样硬化斑块积分采用Crouse法.对血管内皮细胞功能、动脉硬化与冠状动脉病变程度进行分析.结果反应性充血引起的肱动脉内径变化在单支组及多支组明显减弱[(9.08±2.28)%、(6.14±2.21)%],与对照组[(15.58±2.20)%]比较,差异有统计学意义(P<0.01).CAD组颈动脉内膜中层厚度(IMT)高于对照组(P<0.05).结论内皮细胞功能障碍和动脉粥样硬化与冠状动脉粥样硬化的病变密切相关.
목적 관찰노년관심병(CAD)환자혈관내피서장공능、동맥경화적상황급여관상동맥병변적상관성.방법 선택경관상동맥조영학진위CAD적환자90례(CAD조),관상동맥조영증실무관상동맥협착병무기타질병사적환자30례위대조조,채용이유초성검측굉동맥내피의뢰성화비의뢰성서장공능급동맥내막적변화,응용이유채색다보륵초성검사경동맥、고동맥,관찰관강、관경、내막급유무반괴、혈류변화、혈류빈보형태급성질.동맥죽양경화반괴적분채용Crouse법.대혈관내피세포공능、동맥경화여관상동맥병변정도진행분석.결과 반응성충혈인기적굉동맥내경변화재단지조급다지조명현감약[(9.08±2.28)%、(6.14±2.21)%],여대조조[(15.58±2.20)%]비교,차이유통계학의의(P<0.01).CAD조경동맥내막중층후도(IMT)고우대조조(P<0.05).결론 내피세포공능장애화동맥죽양경화여관상동맥죽양경화적병변밀절상관.
Objective To investigate the endothelial function and atherosclerosis in patients with coronary artery disease (CAD).Methods Two-dimensional echocardiography (2-DE) was used tomeasure changes in brachial artery inner diameter as parameter of endothelium-dependant and endothelium-nondependant vascular diastolic function and pathologic characters of carotid atherosclerosis in 90 elderly CAD patients and 30 controls.Results Endothelium-dependant vascular diastolic function and endothelium-non dependant diastolic function were significantly decreased in CAD group as compared with control group [(9.08±2.28)% and (6.14±2.21)% vs.(15.58±2.20)%, P<0.01].The carotid intima-media thickness and plaque score were significantly increased in CAD group as compared with control group.Conclusions There are correlations of endothelium dysfunction and carotid atherosclerosis are relatied to with coronary atherosclerosis.