中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2008年
9期
790-793
,共4页
苏兆安%沈洁%姚克%张丽霞%滕艳
囌兆安%瀋潔%姚剋%張麗霞%滕豔
소조안%침길%요극%장려하%등염
脉络膜肿瘤%血管瘤%光化学疗法%荧光素血管造影术
脈絡膜腫瘤%血管瘤%光化學療法%熒光素血管造影術
맥락막종류%혈관류%광화학요법%형광소혈관조영술
Choroid neoplasms%Hemangioma%Photochemotherapy%Fluorescein angiography
目的 观察组合光斑光动力疗法(PDT)治疗孤立性脉络膜血管瘤的疗效和安全性.方法 为回顾性系列病例研究.经眼底镜、荧光素眼底血管造影、眼底彩色照相及B超检查,确诊孤立性脉络膜血管瘤患者10例,均只行一次组合光斑PDT治疗.术前最佳矫正视力为眼前数指至0.3,B超检查肿瘤最大直线距离为5.5～9.9 mm,平均6.8 mm;最大厚度1.1～3.8 mm,平均2.7 mm,4例伴视网膜脱离.PDT治疗为注射用维替泊芬6 mg/m2体表面积,10 min推注完毕,5 min后行689 nm激光照射,激光参数50 J/cm2,时间83 s.光斑大小3～5 mm,治疗2～3个光斑,根据肿瘤大小及形状治疗光斑可以部分重叠,术后随访3.0～15.0个月,平均8.5个月.结果 组合光斑PDT治疗后最后一次随访视力为眼前数指至1.0,7例患者提高2行以上,3例稳定.其中2例B超检查提示肿瘤测不出.8例肿瘤最大厚度0.5～2.7 mm,平均1.9 mm,最大直线距离4.2～8.3 mm,平均6.4 mm,2例视网膜脱离消失,有视网膜色素上皮改变.结论 组合光斑PDT治疗孤立性脉络膜血管瘤安全有效,可以使瘤体萎缩,视网膜脱离消失或减轻,视力提高.
目的 觀察組閤光斑光動力療法(PDT)治療孤立性脈絡膜血管瘤的療效和安全性.方法 為迴顧性繫列病例研究.經眼底鏡、熒光素眼底血管造影、眼底綵色照相及B超檢查,確診孤立性脈絡膜血管瘤患者10例,均隻行一次組閤光斑PDT治療.術前最佳矯正視力為眼前數指至0.3,B超檢查腫瘤最大直線距離為5.5～9.9 mm,平均6.8 mm;最大厚度1.1～3.8 mm,平均2.7 mm,4例伴視網膜脫離.PDT治療為註射用維替泊芬6 mg/m2體錶麵積,10 min推註完畢,5 min後行689 nm激光照射,激光參數50 J/cm2,時間83 s.光斑大小3～5 mm,治療2～3箇光斑,根據腫瘤大小及形狀治療光斑可以部分重疊,術後隨訪3.0～15.0箇月,平均8.5箇月.結果 組閤光斑PDT治療後最後一次隨訪視力為眼前數指至1.0,7例患者提高2行以上,3例穩定.其中2例B超檢查提示腫瘤測不齣.8例腫瘤最大厚度0.5～2.7 mm,平均1.9 mm,最大直線距離4.2～8.3 mm,平均6.4 mm,2例視網膜脫離消失,有視網膜色素上皮改變.結論 組閤光斑PDT治療孤立性脈絡膜血管瘤安全有效,可以使瘤體萎縮,視網膜脫離消失或減輕,視力提高.
목적 관찰조합광반광동력요법(PDT)치료고립성맥락막혈관류적료효화안전성.방법 위회고성계렬병례연구.경안저경、형광소안저혈관조영、안저채색조상급B초검사,학진고립성맥락막혈관류환자10례,균지행일차조합광반PDT치료.술전최가교정시력위안전수지지0.3,B초검사종류최대직선거리위5.5～9.9 mm,평균6.8 mm;최대후도1.1～3.8 mm,평균2.7 mm,4례반시망막탈리.PDT치료위주사용유체박분6 mg/m2체표면적,10 min추주완필,5 min후행689 nm격광조사,격광삼수50 J/cm2,시간83 s.광반대소3～5 mm,치료2～3개광반,근거종류대소급형상치료광반가이부분중첩,술후수방3.0～15.0개월,평균8.5개월.결과 조합광반PDT치료후최후일차수방시력위안전수지지1.0,7례환자제고2행이상,3례은정.기중2례B초검사제시종류측불출.8례종류최대후도0.5～2.7 mm,평균1.9 mm,최대직선거리4.2～8.3 mm,평균6.4 mm,2례시망막탈리소실,유시망막색소상피개변.결론 조합광반PDT치료고립성맥락막혈관류안전유효,가이사류체위축,시망막탈리소실혹감경,시력제고.
Objective To assess the clinical effect of combination facula photodynamic therapy (PDT) on patients with circumscribed choroidal hemangioma.Methods It was a retrospective case series.Ten cases of circumscribed choroidal hemangioma were diagnosed by ophthalmoscopy,fundna fluorescein angiography and B-scanning ultrasound examination.Clinical data of these cases were retrospectively analyzed.All of these patients had undergone combination facula PDT.The best corrected visual acuity before PDT was FC to 0.3.The maximum diameter of the tumor was 5.5-9.9 mm and averaged 6.8 mm. The maximum thickness of the tumor was 1.1-3.8 mm and averaged 2.7 mm. Four patients suffered from retinal detachment. The intravenous injection of visudyne (6 mg/m2) was performed in 10 minutes.Five minutes later,later irradiation (wave length 689 nm) was performed with the parameters of 50 J/cm2,83 s,and 2 to 3 spots.The follow-up period was 3.0 to 15.0 months (mean 8.5 months).Results The visual acuity in the last examination after treatment was FC-1.0,which was 2-line increased in 7 patients and was steady in 3 patients.B-scanning ultrasound examination showed that the hemangioma was undetectable in 2 patients,and in the other 8 patients,the hemangioma had the diameter of 4.2 to 8.3 mm (average 6.4 mm) and the thickness was 0.5 to 2.7 mm (average 1.9 mm).Retina detachment disappeared in 2 patients .Conclusions Combination facula PDT may lead to the shrinking of choroidal hemangioma,disappearance of subretinal fluid,reattachment of retina and the increase or saving of the visual acuity.It is a effective and safe treatment for the macular circumscribed choroidal hemangioma.
