CAJ | 학술논문

目的研究中国人β3肾上腺素能受体（ADR β3）基因Trp64Arg突变对肥胖、血脂、血压、心率等的影响。方法对受检者198人进行ADR β3基因Trp64Arg突变基因型的检测，并测体重指数（BMI）、血糖、血脂、血压，心率等。结果本调查组β3肾上腺素能受体基因Trp64Arg突变率为20.20%，BMI增高与其基因突变有关。基因突变者血脂偏低。结论 ADR β3基因突变参与中国人体重的增加和血脂水平的调节，与血压、心率无明显相关性。
목적연구중국인β3신상선소능수체（ADR β3）기인Trp64Arg돌변대비반、혈지、혈압、심솔등적영향。방법대수검자198인진행ADR β3기인Trp64Arg돌변기인형적검측，병측체중지수（BMI）、혈당、혈지、혈압，심솔등。결과본조사조β3신상선소능수체기인Trp64Arg돌변솔위20.20%，BMI증고여기기인돌변유관。기인돌변자혈지편저。결론 ADR β3기인돌변삼여중국인체중적증가화혈지수평적조절，여혈압、심솔무명현상관성。
Objective　To investigate the influence of Trp64Arg mutation of β3-adrenergic receptor on obesity, plasma lipid, blood pressure and heart rate.Methods　Genotype of Trp64Arg mutation of ADR β3 gene and several clinical variables including body mass index BMI, plasma glucose, plasma lipid, blood pressure, heart rate and so on were determined in 198 Chinese who took their physical examinations.Results　The frequency of Trp64Arg mutation of ADR β3 gene in above 198 Chinese was 20.20%. The mutation of ADR β3 gene was found to have some associations with the increase of BMI. Individuals with Trp64Arg mutation of ADR β3 gene were also found to have lower plasma lipid levels.Conclusion　The mutation of ADR β3 seems to be related with over-weight. It also seems to have association with plasma lipid regulation. But it has no relation with blood pressure or heart rate.