CAJ | 학술논문

目的:探讨Survivin在食管癌患者外周血中的表达与化疗敏感性及预后的关系.方法:采用荧光定量RT-PCR法检测Survivin mRNA在103例食管癌患者和正常人外周血中的表达,分析食管癌患者外周血中Survivin mRNA表达水平高低与不同化疗方案敏感性的关系,以及对生存期的影响.结果:FP、TP方案的疗效与外周血Survivin mRNA表达水平呈负相关,而NP方案疗效与外周血Survivin mRNA表达水平无关.总生存期与外周血Survivin mRNA表达水平有关,外周血Survivin mRNA表达水平低,总生存期长.结论:检测外周血Survivin mRNA对食管癌生存期预测以及化疗方案选择具有一定的指导作用.
목적:탐토Survivin재식관암환자외주혈중적표체여화료민감성급예후적관계.방법:채용형광정량RT-PCR법검측Survivin mRNA재103례식관암환자화정상인외주혈중적표체,분석식관암환자외주혈중Survivin mRNA표체수평고저여불동화료방안민감성적관계,이급대생존기적영향.결과:FP、TP방안적료효여외주혈Survivin mRNA표체수평정부상관,이NP방안료효여외주혈Survivin mRNA표체수평무관.총생존기여외주혈Survivin mRNA표체수평유관,외주혈Survivin mRNA표체수평저,총생존기장.결론:검측외주혈Survivin mRNA대식관암생존기예측이급화료방안선택구유일정적지도작용.
Objective:To investigate the relationship of expression of survivin in the peripheral blood of esophageal cancer to chemosensitivity and prognostic significance. Methods:Real-time fluorescence quantitative PCR was used to detect the expression of survivin mRNA in the peripheral blood samples abtained from 103 patients with esophageal cancer. Meanwhile, the correlation of expression of survivin in the peripheral blood of esophageal cancer to chemosensitivity and prognostic significance was identified. Results:The expression of survivin mRNA in the blood was inversely correlated with the effect of FP and TP regimens. However, the expression of survivin mRNA in the blood was not correlated with the effect of the NP regimen. Moreover, overall survival(OS) for patients with high survivin mRNA expression was less than that for patients with low survivin mRNA group expression.Conclusion:The expression of survivin mRNA in the peripheral blood of patients with esophageal cancer can prognosticate OS and choice the regimen of chemotherapy.