CAJ | 학술논문

用HPLC法测定了小鼠单剂量(20mg/kg)尾静脉注射伊曲康唑纳米粒及其市售注射剂后心、肝、脾、肺、肾、脑和血浆中的药物浓度.结果表明,伊曲康唑纳米粒在肺中的AUC为注射剂的32.94倍;在心、肾组织的蓄积量减少,在各组织中的半衰期延长,尤以肝、脾、肺为甚.说明伊曲康唑纳米粒的肺靶向性明显优于市售注射剂.
용HPLC법측정료소서단제량(20mg/kg)미정맥주사이곡강서납미립급기시수주사제후심、간、비、폐、신、뇌화혈장중적약물농도.결과표명,이곡강서납미립재폐중적AUC위주사제적32.94배;재심、신조직적축적량감소,재각조직중적반쇠기연장,우이간、비、폐위심.설명이곡강서납미립적폐파향성명현우우시수주사제.
Itraconazole nanoparticles and its injection were injected intravenously with single dose of 20 mg/kg to mice.The drug concentrations in heart,liver,spleen,lung,kidney,brain and plasma were determined by HPLC.The results showed that the A UC in lung of prepared nanoparticles was 32.94 times as that of injection.Compared with the injection,the nanoparticles had less accumulation in heart and kidney and longer t_(1/2) in all tissues especially in liver,spleen and lung.It was indicated that the lung-targeted characteristic of nanoparticles Was superior to injection.