CAJ | 학술논문

目的观察老年男性T2DM患者血清硫酸脱氢表雄酮 (DHEA-S)含量的变化,初步探讨其临床意义.方法放免法测定82例老年男性T2DM患者(DM组)血清DHEA-S,并与35名男性健康老年人(NC组)比较.结果 DM组血清DHEA-S显著降低,合并微血管病变组显著低于无微血管病变组,肥胖者明显低于体重正常者.多元Logistic回归分析结果显示,与血清DHEA-S降低有独立相关性的因素分别是增龄、BMI增加、微血管并发症及FPG、Ins、C-P、ApoB、TG增加.结论老年男性T2DM患者血清DHEA-S降低,并与DM危险因素,如机体老化、肥胖、微血管病变、FPG控制差、高胰岛素血症、C-P高值、Apo B高值及高TG血症密切相关.
목적 관찰노년남성T2DM환자혈청류산탈경표웅동 (DHEA-S)함량적변화,초보탐토기림상의의.방법 방면법측정82례노년남성T2DM환자(DM조)혈청DHEA-S,병여35명남성건강노년인(NC조)비교.결과 DM조혈청DHEA-S현저강저,합병미혈관병변조현저저우무미혈관병변조,비반자명현저우체중정상자.다원Logistic회귀분석결과현시,여혈청DHEA-S강저유독립상관성적인소분별시증령、BMI증가、미혈관병발증급FPG、Ins、C-P、ApoB、TG증가.결론 노년남성T2DM환자혈청DHEA-S강저,병여DM위험인소,여궤체노화、비반、미혈관병변、FPG공제차、고이도소혈증、C-P고치、Apo B고치급고TG혈증밀절상관.
Objective To study the change of serum concentration of dehydroepiandrosterone sulfate (DHEA-S) in elderly men with type 2 diabetes mellitus (T2DM) and to explore the clinical significance of its change. Methods Serum DHEA-S was measured by radioimmunoassay in 82 elderly men with T2DM and 35 healthy elderly men as controls (NC). Results Serum DHEA-S was significantly lower ［(2.63±1.49）μmol/L］ in DM group than in NC group ［(4.06±1.76）μmol/L,P<0.01］. It was greatly decreased in subgroup with microangiopathy of DM ［(2.01±1.33）μmol/L］ than in subgroup without microangiopathy ［(3.03±1.46）μmol/L，P<0.01］. It was markedly decreased in the obese patients ［(2.11 ± 1.52）μmol/L］ as compared with patients whose body mass index was normal ［(3.09 ± 1.47）μmol/L，P<0.01］. Mutiple logistic regression analysis showed that there were independent correlations of the decerased serum DHEA-S with age increase, raised body mass index, microvascular complications, and incremental fasting levels of glucose, insulin, Cpeptide, apolipoprotein B and triglyceride (P<0.01 or <0.05). Conclusions Serum DHEA in elderly men with T2DM is lower and is closely associated with risk factors including aging, obesity, microangiopathy, hyperglycemia, hyperinsulinemia, high levels of Cpeptide, apolipoprotein B and triglyce ride.