CAJ | 학술논문

头孢菌素类抗生素是一类疗效和安全性好、临床应用广泛的抗菌药物，但由于可能引发过敏反应，故有学者认为须在注射给药前进行皮肤敏感试验（以下简称为“皮试”）。但对头孢菌素类抗生素是否必须进行皮试、如何进行皮试和皮试的临床意义等问题，目前国内、外均还无定论。本文介绍头孢菌素类抗生素导致过敏反应发生的机制，归纳国外对临床使用头孢菌素类抗生素前进行皮试的必要性的研究结果，发现虽观点不一，但认为进行头孢菌素类抗生素皮试意义不大的依据较强。
두포균소류항생소시일류료효화안전성호、림상응용엄범적항균약물，단유우가능인발과민반응，고유학자인위수재주사급약전진행피부민감시험（이하간칭위“피시”）。단대두포균소류항생소시부필수진행피시、여하진행피시화피시적림상의의등문제，목전국내、외균환무정론。본문개소두포균소류항생소도치과민반응발생적궤제，귀납국외대림상사용두포균소류항생소전진행피시적필요성적연구결과，발현수관점불일，단인위진행두포균소류항생소피시의의불대적의거교강。
Cephalosporins, one of the most effective antibacterial agents with a wide clinical application, a signiifcant therapeutic effect and a high safety, is often abandoned by doctors due to concerns for allergy. Diagnostic skin tests are designed to screen patients with possibility of potential allergy. However, no conclusion has been demonstrated on their necessity. Therefore, researches and clinical experiences abroad are summarized in this article, in which more evidences showed that diagnostic skin tests for cephalosporins were not meaningful.