国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
12期
1726-1728
,共3页
川崎病%丙种球蛋白%不同剂量%临床疗效
川崎病%丙種毬蛋白%不同劑量%臨床療效
천기병%병충구단백%불동제량%림상료효
Kawasaki disease%All globulin%Different doses%Clinical curative effect
目的 探讨不同剂量丙种球蛋白治疗小儿川崎病的临床疗效.方法 我院2006年10月至2010年12月收治的120例川崎病患儿,随机分为A、B、C三组,每组40例,三组患者均采用静脉注射内种球蛋白进行治疗,A组静脉滴注丙种球蛋白 2g/kg,B组静脉滴注丙种球蛋白1g/(kg·d)×2d;C组静脉滴注丙种球蛋白0.4 g/(kg·d)×5d,其他治疗相同.观测患儿退热、淋巴结肿大消退、粘膜充血消退、皮疹消退、手足症状消退时间及冠状动脉损害发生率(CAL).结果 A组患儿退热、淋巴结肿大消退、粘膜充血消退、皮疹消退、手足症状消退时间明显短于B、C两组,差异有显著性(P＜0.05);B组患儿淋巴结肿大消退、粘膜充血消退、皮疹消退、手足症状消退时间与C组比较,差异无显著性(P＞0.05).A、B、C 三组CAL发生率分别为27.5％、30.0％、27.5％,差异无显著性(P＞0.05),三组均未见明显不良反应.结论 静脉丙种球蛋白2 g/kg单次给药治疗川崎病,能更好地退热,并有效预防冠状动脉并发症的发生,疗效满意,值得临床推广.
目的 探討不同劑量丙種毬蛋白治療小兒川崎病的臨床療效.方法 我院2006年10月至2010年12月收治的120例川崎病患兒,隨機分為A、B、C三組,每組40例,三組患者均採用靜脈註射內種毬蛋白進行治療,A組靜脈滴註丙種毬蛋白 2g/kg,B組靜脈滴註丙種毬蛋白1g/(kg·d)×2d;C組靜脈滴註丙種毬蛋白0.4 g/(kg·d)×5d,其他治療相同.觀測患兒退熱、淋巴結腫大消退、粘膜充血消退、皮疹消退、手足癥狀消退時間及冠狀動脈損害髮生率(CAL).結果 A組患兒退熱、淋巴結腫大消退、粘膜充血消退、皮疹消退、手足癥狀消退時間明顯短于B、C兩組,差異有顯著性(P＜0.05);B組患兒淋巴結腫大消退、粘膜充血消退、皮疹消退、手足癥狀消退時間與C組比較,差異無顯著性(P＞0.05).A、B、C 三組CAL髮生率分彆為27.5％、30.0％、27.5％,差異無顯著性(P＞0.05),三組均未見明顯不良反應.結論 靜脈丙種毬蛋白2 g/kg單次給藥治療川崎病,能更好地退熱,併有效預防冠狀動脈併髮癥的髮生,療效滿意,值得臨床推廣.
목적 탐토불동제량병충구단백치료소인천기병적림상료효.방법 아원2006년10월지2010년12월수치적120례천기병환인,수궤분위A、B、C삼조,매조40례,삼조환자균채용정맥주사내충구단백진행치료,A조정맥적주병충구단백 2g/kg,B조정맥적주병충구단백1g/(kg·d)×2d;C조정맥적주병충구단백0.4 g/(kg·d)×5d,기타치료상동.관측환인퇴열、림파결종대소퇴、점막충혈소퇴、피진소퇴、수족증상소퇴시간급관상동맥손해발생솔(CAL).결과 A조환인퇴열、림파결종대소퇴、점막충혈소퇴、피진소퇴、수족증상소퇴시간명현단우B、C량조,차이유현저성(P＜0.05);B조환인림파결종대소퇴、점막충혈소퇴、피진소퇴、수족증상소퇴시간여C조비교,차이무현저성(P＞0.05).A、B、C 삼조CAL발생솔분별위27.5％、30.0％、27.5％,차이무현저성(P＞0.05),삼조균미견명현불량반응.결론 정맥병충구단백2 g/kg단차급약치료천기병,능경호지퇴열,병유효예방관상동맥병발증적발생,료효만의,치득림상추엄.
Objective To explore the clinical curative effect of different doses of c-type globulin in treating pediatric of kawasaki disease.Methods The clinical materials of 120 cases of kawasaki disease from July 2006 to August 2010 in our hospital were retrospectively analyzed,120 children were randomly divided into A,B and C three groups,40 cases in each group,patients of three groups all used intravenous immunoglobulin c-type treatment,group A c-type globulin intravenous injection 2 g/kg; group B c-type globulin intravenous injection 1 g/kg × 2 d; group C c-type globulin intravenous injection 0.4 g/(kg.d) × 5 d,each other the same treatment.We observed the lymph node enlargement,mucous membrane,fever,rash and congestion subsidise pleomorphism brothers symptoms subsided time and coronary damage rate (CAL),and the statistical analysis was also conducted.Results The group A antifebrile,lymph node enlargement,mucous membrane,rash and congestion subsidise pleomorphism brothers symptoms subsided time than group B and C,were statistically significantly shorter (P＜ 0.05).There was statistically significant difference between group B and C (P＞0.05),difference of CAL in group A,B and C( 27.5％ vs 30.0％vs 27.5％ ) was statistically significant (P＞ 0.05),among three groups there were no obvious adverse reactions.Conclusion Intravenous immunoglobulin c-type 2 g/kg,single dose kawasaki disease treatment,the better antifebrile,and effectively to prevent coronary artery complications,and the results are satisfactory,worthy in clinical promotion.
