CAJ | 학술논문

目的探讨18F-脱氧葡萄糖(FDG)PET/CT显像探测临床可疑神经系统副肿瘤综合征(PNS)患者潜在肿瘤病灶的应用价值.方法回顾性分析20例可疑PNS患者18F-FDG PET/CT显像资料,对所有患者行随访病理检查或临床最终诊断,并将结果与PET/CT显像和随访结果进行比较.结果 20例中PET/CT显像发现可疑恶性病变或既往肿瘤复发和(或)转移者9例,阴性11例.9例阳性者中3例为假阳性.PET/CT显像对PNS恶性肿瘤检出的灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为6/6,78.57%(11/14),85.00%(17/20),6/9和100.00%(11/11).6例真阳性中4例治疗方案得以修正,经抗肿瘤和免疫疗法后神经异常症状得到改善.结论 18F-FDG PET/CT显像在可疑PNS中的应用有积极意义,有助于发现恶性肿瘤,也能对肿瘤分期提供帮助.
목적 탐토18F-탈양포도당(FDG)PET/CT현상탐측림상가의신경계통부종류종합정(PNS)환자잠재종류병조적응용개치.방법 회고성분석20례가의PNS환자18F-FDG PET/CT현상자료,대소유환자행수방병리검사혹림상최종진단,병장결과여PET/CT현상화수방결과진행비교.결과 20례중PET/CT현상발현가의악성병변혹기왕종류복발화(혹)전이자9례,음성11례.9례양성자중3례위가양성.PET/CT현상대PNS악성종류검출적령민도、특이성、준학성、양성예측치화음성예측치분별위6/6,78.57%(11/14),85.00%(17/20),6/9화100.00%(11/11).6례진양성중4례치료방안득이수정,경항종류화면역요법후신경이상증상득도개선.결론 18F-FDG PET/CT현상재가의PNS중적응용유적겁의의,유조우발현악성종류,야능대종류분기제공방조.
Objective To evaluate 18F-fluorodeoxyglucose (FDG) PET/CT in detecting occult malignancy in patients with suspected paraneoplastic neurological syndrome (PNS).Methods Twenty consecutive patients who underwent PET/CT scanning with the indication of suspected PNS were retrospectively reviewed.The gold standard of PNS was either cytology or clinical follow-up, and the final diagnosis was compared with PET/CT findings.Results Of the 20 patients, six were PNS.PET/CT detected nine cases.Six were true positive and three were false positive.The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT were 100% (6/6), 78.57% (11/14), 85.00% (17/20),66.7% (6/9) and 100.00% ( 11/11 ) respectively.The treatment plan was modified based on the PET/CT results in 4 patients.Conclusions 18F-FDG PET/CT may play a role in detecting the underlying malignancy of PNS.It is also valuable in staging of the malignancy thus providing information for therapy decision making.