吡格列酮对肥胖小鼠原代棕色脂肪细胞分化和功能基因表达的影响
필격렬동대비반소서원대종색지방세포분화화공능기인표체적영향
Effects of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells in mice with diet-induced obesity
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2011年 11期 947-949 ,共3页

    胡淼%刘娟%王龙%丁国宪

    호묘%류연%왕룡%정국헌

    吡格列酮%棕色脂肪%PPARγ%解耦联蛋白 吡格列酮%棕色脂肪%PPARγ%解耦聯蛋白
    필격렬동%종색지방%PPARγ%해우련단백
    Pioglitazone%Brown adipose tissue%PPA Rγ′%Uncoupling protein-1
    观察吡格列酮对肥胖小鼠原代棕色脂肪(brown adipose tissue,BAT)细胞分化和功能基因表达的影响,并为治疗肥胖相关疾病寻找新思路.结果显示吡格列酮通过增强特异基因表达、促进分化成脂、提高线粒体功能等方面增强BAT细胞功能(P＜0.05)；这可能是吡格列酮改善机体代谢的重要原因.
    관찰필격렬동대비반소서원대종색지방(brown adipose tissue,BAT)세포분화화공능기인표체적영향,병위치료비반상관질병심조신사로.결과현시필격렬동통과증강특이기인표체、촉진분화성지、제고선립체공능등방면증강BAT세포공능(P＜0.05)；저가능시필격렬동개선궤체대사적중요원인.
    The effect of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells was detected for the new treatment of obesity and type 2 diabetes.The results showed that pioglitazone promoted the differentiation and function of brown adipocytes( P＜0.05 ).
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