中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
2期
185-187
,共3页
季中华%乔瑞冬%王昊%范喜红
季中華%喬瑞鼕%王昊%範喜紅
계중화%교서동%왕호%범희홍
神经肌肉非去极药/投药和剂量%麻醉,全身%插管法,气管内
神經肌肉非去極藥/投藥和劑量%痳醉,全身%插管法,氣管內
신경기육비거겁약/투약화제량%마취,전신%삽관법,기관내
Neuromuscular nondepolarizing agents/AD%Anesthesia,general%Intubation,intratracheal
目的 观察预注不同剂量肌松药在全身麻醉下气管内插管术的影响.方法 ASA Ⅰ～Ⅱ级择期手术患者120例随机分为6组(n=20),分别为维库溴铵组(V1、V2、V3)和顺式阿曲库铵组(C1、C2、C3),其中V1、C1为对照组,V2、V3、C2、C3为预注组.所有患者给予丙泊酚血浆TCI 3 μg/ml,芬太尼3μg/kg全麻诱导后,对照组:V1、C1分别静注2倍ED95剂量维库溴铵和3倍ED95剂量顺式阿曲库铵.预注组:V2、V3、C2、C3分别预注10、20μg/kg维库溴铵和15、30μg/kg顺式阿曲库铵,待肌松起效后给予剩余的插管剂量肌松药.观察肌松起效时间(T1=0)、气管插管条件.结果 6组的气管插管优良率均为100％.预注组V2、V3、C2、C3的起效时间(T1=0)明显缩短[(80.5±7.2) vs (146±10.7); (79.8±6.5) vs (146±10.7);(138.5±7.2)vs(218±10.7)；(127.1±6.5)vs(218±10.7)].差异有统计学意义(P＜0.05).结论 预注不同剂量肌松药能显著缩短起效时间,加大预注量并不能进一步缩短肌松药的起效时间.
目的 觀察預註不同劑量肌鬆藥在全身痳醉下氣管內插管術的影響.方法 ASA Ⅰ～Ⅱ級擇期手術患者120例隨機分為6組(n=20),分彆為維庫溴銨組(V1、V2、V3)和順式阿麯庫銨組(C1、C2、C3),其中V1、C1為對照組,V2、V3、C2、C3為預註組.所有患者給予丙泊酚血漿TCI 3 μg/ml,芬太尼3μg/kg全痳誘導後,對照組:V1、C1分彆靜註2倍ED95劑量維庫溴銨和3倍ED95劑量順式阿麯庫銨.預註組:V2、V3、C2、C3分彆預註10、20μg/kg維庫溴銨和15、30μg/kg順式阿麯庫銨,待肌鬆起效後給予剩餘的插管劑量肌鬆藥.觀察肌鬆起效時間(T1=0)、氣管插管條件.結果 6組的氣管插管優良率均為100％.預註組V2、V3、C2、C3的起效時間(T1=0)明顯縮短[(80.5±7.2) vs (146±10.7); (79.8±6.5) vs (146±10.7);(138.5±7.2)vs(218±10.7)；(127.1±6.5)vs(218±10.7)].差異有統計學意義(P＜0.05).結論 預註不同劑量肌鬆藥能顯著縮短起效時間,加大預註量併不能進一步縮短肌鬆藥的起效時間.
목적 관찰예주불동제량기송약재전신마취하기관내삽관술적영향.방법 ASA Ⅰ～Ⅱ급택기수술환자120례수궤분위6조(n=20),분별위유고추안조(V1、V2、V3)화순식아곡고안조(C1、C2、C3),기중V1、C1위대조조,V2、V3、C2、C3위예주조.소유환자급여병박분혈장TCI 3 μg/ml,분태니3μg/kg전마유도후,대조조:V1、C1분별정주2배ED95제량유고추안화3배ED95제량순식아곡고안.예주조:V2、V3、C2、C3분별예주10、20μg/kg유고추안화15、30μg/kg순식아곡고안,대기송기효후급여잉여적삽관제량기송약.관찰기송기효시간(T1=0)、기관삽관조건.결과 6조적기관삽관우량솔균위100％.예주조V2、V3、C2、C3적기효시간(T1=0)명현축단[(80.5±7.2) vs (146±10.7); (79.8±6.5) vs (146±10.7);(138.5±7.2)vs(218±10.7)；(127.1±6.5)vs(218±10.7)].차이유통계학의의(P＜0.05).결론 예주불동제량기송약능현저축단기효시간,가대예주량병불능진일보축단기송약적기효시간.
Objective To study the effects of different priming dose of muscle relaxant at the onset and endotracheal intubation conditions.Methods 120 ASA Ⅰ～Ⅱ grade patients were randomly divided into 6 groups (n=6),vecuronium group (V 1,V2,V3) and cis-atrscurium group (C1,C2,C3).All patients were induced with propofol plasma (TCI)3 μg/ml,fentanil3 μg/kg.The V1 and C1 group were not given priming dose,and the V2,V3,C2,C3 groups were given priming dose of 10 μg/kg,20 μg/kg vecuronium and 15 μg/kg,30 μg/kg cis-atracurium.Intubating conditions were evaluated,and the onset time was monitored with train-of-four (TOF) technique.Results Intubating conditions were excellent in all patients.The onset time of priming groups of the four different doses was significantly shorter than that of the nonpriming group [(80.5±7.2) vs (146±10.7);(79.8±6.5) vs (146±10.7);(138.5±7.2) vs (218±10.7) ; (127.1±6.5) vs (218±10.7),P ＜ 0.05 ].Conclusions The taking-effect time of priming dose of muscle relaxant was significantly shorter than that of the nonpriming dose group.Increasing the priming dose not decrease onset time more than the smaller dose.
