CAJ | 학술논문

微环境乏氧是肿瘤组织内常见的现象之一,研究表明乏氧通过激活多条DNA损伤效应信号途径诱发肿瘤细胞的基因组不稳定与肿瘤的侵袭与转移及化放疗的抵抗密切相关.目前微环境乏氧对肿瘤细胞接受放化疗后DNA损伤修复3条主要途径错配修复(MMR)、同源重组(HR)和非同源性末端连接(NHEJ)这3种方式研究最为广泛.
미배경핍양시종류조직내상견적현상지일,연구표명핍양통과격활다조DNA손상효응신호도경유발종류세포적기인조불은정여종류적침습여전이급화방료적저항밀절상관.목전미배경핍양대종류세포접수방화료후DNA손상수복3조주요도경착배수복(MMR)、동원중조(HR)화비동원성말단련접(NHEJ)저3충방식연구최위엄범.
Microenviroment hypoxia is one of the common phenomenon in cancer,studies have indiacat-ed that hypoxia induces genetic instability via activating many DNA danlage-repair signal pathways,which asso-ciates with tumor invasion and resistance and chemi-radiotherapy resistivity.Here,we overview three main DNA damage-repair pathways:mismatch repair,homologous recombination and non-homologous end joining,and how hypoxia influences their mechanisms.