CAJ | 학술논문

目的分析其眼压昼夜变化规律,以期为青光眼的个性化治疗提供参考依据.方法收集2006年4月至2009年4月上海市北站医院和复旦大学附属眼耳鼻喉科医院门诊的原发性开角型青光眼患者102例及正常志愿者83名,进行24 h眼压测量,用非接触性眼压计从8 am起每隔2 h测1次眼压,零点至6 am为唤醒后即刻坐位眼压.结果二组之间峰值眼压[正常组右眼(16.0±2.7)mm Hg,左眼(16.2±2.7)mm Hg;POAG组右眼(25.3±5.6)mm Hg,左眼(24.8±5.1)mm Hg]、谷值眼压[正常组右眼(11.1±2.5)mm Hg,左眼(11.0±2.3)mm Hg;POAG组右眼(16.3±3.7)mm Hg,左眼(16.2±3.3)mm Hg]、平均眼压[正常组右眼(13.4±2.5)mm Hg,左眼(13.4±2.5)mm Hg;POAG组右眼(19.9±4.3)mm Hg,左眼(19.8±3.8)mm Hg]及眼压波动值[正常组右眼(5.0±1.6)mm Hg,左眼(5.2±1.7)mm Hg;POAG组右眼(9.1±3.6)mm Hg,左眼(8.6±3.8)mm Hg]的差异均具有统计学意义(均P＜0.01),正常组59.6%,POAG组73.5%的峰值眼压位于门诊工作时间以外;尤其是在零点至早上6点这一时间段,正常组50%,POAG组64.7%的峰值位于凌晨0:00至06:00.结论通过对比分析,24 h眼压可以为我们提供治疗前的基础状态,从而为个性化治疗提供详实的资料.建议有条件的话,应该将24 h昼夜眼压监测作为开角型青光眼的检查常规.
목적 분석기안압주야변화규률,이기위청광안적개성화치료제공삼고의거.방법 수집2006년4월지2009년4월상해시북참의원화복단대학부속안이비후과의원문진적원발성개각형청광안환자102례급정상지원자83명,진행24 h안압측량,용비접촉성안압계종8 am기매격2 h측1차안압,영점지6 am위환성후즉각좌위안압.결과 이조지간봉치안압[정상조우안(16.0±2.7)mm Hg,좌안(16.2±2.7)mm Hg;POAG조우안(25.3±5.6)mm Hg,좌안(24.8±5.1)mm Hg]、곡치안압[정상조우안(11.1±2.5)mm Hg,좌안(11.0±2.3)mm Hg;POAG조우안(16.3±3.7)mm Hg,좌안(16.2±3.3)mm Hg]、평균안압[정상조우안(13.4±2.5)mm Hg,좌안(13.4±2.5)mm Hg;POAG조우안(19.9±4.3)mm Hg,좌안(19.8±3.8)mm Hg]급안압파동치[정상조우안(5.0±1.6)mm Hg,좌안(5.2±1.7)mm Hg;POAG조우안(9.1±3.6)mm Hg,좌안(8.6±3.8)mm Hg]적차이균구유통계학의의(균P＜0.01),정상조59.6%,POAG조73.5%적봉치안압위우문진공작시간이외;우기시재영점지조상6점저일시간단,정상조50%,POAG조64.7%적봉치위우릉신0:00지06:00.결론 통과대비분석,24 h안압가이위아문제공치료전적기출상태,종이위개성화치료제공상실적자료.건의유조건적화,응해장24 h주야안압감측작위개각형청광안적검사상규.
Objective To analyze the discipline of intraocular pressure (IOP) variation, through circadian intraocular pressure monitoring in primary open-angle glaucoma (POAG) patients and normal controls, with a view to provide basis for individualized treatment of glaucoma. Methods Subjects were enrolled from the outpatients of Shanghai Beizhan Hospital and Eye and ENT Hospital of Fudan University,which were diagnosed as primary open angle glaucoma, from April 2006 to April 2009. Totally there were 102 cases of patients and 83 cases of normal volunteers. All the subjects accepted 24-hour IOP measurements using non-contact tonometer every two hours starting from 8:00 am. And the IOP between O0:00 to 06:00 am was measured in sitting position immediately after wake up. Results The differences of peak IOP[ (16.0±2.7)mm Hg of right eye and ( 16.2±2.7)mm Hg of left eye in normal group; (25.3±5.6) mm Hg of right eye and (24.8±5.1) mm Hg of left eye in POAG group], valley IOP ( 11.1±2.5) mm Hg of right eye and (11.0±2.3) mm Hg of left eye in normal group; ( 16. 3 ±3.7) mm Hg of right eye and ( 16.2 ±3. 3 ) mm Hg of left eye in POAG group, average IOP (13.4±2.5) mm Hg of right eye and ( 13.4 ± 2.5)mm Hg of left eye in normal group; ( 19.9 ±4.3) mm Hg of right eye and ( 19. 8 ±3. 8) mm Hg of left eye in POAG group), and IOP fluctuations (5.0 ± 1.6) mm Hg of right eye and (5. 2 ± 1.7) mm Hg of left eye in normal group; (9.1 ±3.6) mm Hg of right eye and (8.6±3.8 ) mm Hg of left eye in POAG group between two groups were all of statistically significance (P ＜ 0. 01 ). Notably, the peak IOP of 59. 6% in normal control group and 73.5% in POAG group were outside working hours, especially in the time period from 00:00 to 06:00 am. The peak value of 50% in normal group and 64.7% in POAG group located between 00:00 to 06:00 in the morning. Conclusions By comparison and analysis, 24-hour intraocular pressure measurement could provide us pre-treatment basic state, so as to provide detailed information for individualized treatment. If possible, it is suggested that 24-hour IOP monitoring should be added as a routine examination of primary open angle glaucoma.