肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2008年
8期
545-547
,共3页
胃肿瘤%钙黏着糖蛋白%细胞分化%肿瘤转移
胃腫瘤%鈣黏著糖蛋白%細胞分化%腫瘤轉移
위종류%개점착당단백%세포분화%종류전이
Stomach neoplasms%E-cadherin%Cell differentiation%Neoplasms metastasis
目的 研究胃癌细胞上皮型钙黏附蛋白(E-Cad)表达及其与胃癌Lauren分型、分化程度、临床分期、浸润深度、淋巴结转移和远处转移的关系.方法 连续收集长治医学院附属和济医院胃癌切除术后组织标本80例,按照病理组织分型分为管状腺癌、黏液腺癌、髓样癌及弥漫型癌四组.应用免疫组织化学SP法进行E-Cad检测,对E-Cad表达阳性与胃癌的分化、转移等进行相关分析.结果 80例胃癌组织标本中E-Cad表达率为55.00%,E-Cad在胃癌组织中的表达与胃癌Lauren分型、分化程度、临床分期、浸润深度、淋巴结转移和远处转移显著相关(P＜0.05),而与患者性别、年龄、肿瘤大小等参数无相关性.E-Cad在有淋巴结转移的胃癌原发灶和转移淋巴结中的表达率分别为35.48%和32.26%.E-Cad的表达与有淋巴结转移的胃癌中的原发灶和转移淋巴结呈显著相关(r=0.4978,P＜0.05).结论 免疫组织化学观察发现具有侵袭性组织病理学特征的肿瘤常有E-Cad表达,E-Cad的表达与胃癌分化、侵袭转移密切相关.
目的 研究胃癌細胞上皮型鈣黏附蛋白(E-Cad)錶達及其與胃癌Lauren分型、分化程度、臨床分期、浸潤深度、淋巴結轉移和遠處轉移的關繫.方法 連續收集長治醫學院附屬和濟醫院胃癌切除術後組織標本80例,按照病理組織分型分為管狀腺癌、黏液腺癌、髓樣癌及瀰漫型癌四組.應用免疫組織化學SP法進行E-Cad檢測,對E-Cad錶達暘性與胃癌的分化、轉移等進行相關分析.結果 80例胃癌組織標本中E-Cad錶達率為55.00%,E-Cad在胃癌組織中的錶達與胃癌Lauren分型、分化程度、臨床分期、浸潤深度、淋巴結轉移和遠處轉移顯著相關(P＜0.05),而與患者性彆、年齡、腫瘤大小等參數無相關性.E-Cad在有淋巴結轉移的胃癌原髮竈和轉移淋巴結中的錶達率分彆為35.48%和32.26%.E-Cad的錶達與有淋巴結轉移的胃癌中的原髮竈和轉移淋巴結呈顯著相關(r=0.4978,P＜0.05).結論 免疫組織化學觀察髮現具有侵襲性組織病理學特徵的腫瘤常有E-Cad錶達,E-Cad的錶達與胃癌分化、侵襲轉移密切相關.
목적 연구위암세포상피형개점부단백(E-Cad)표체급기여위암Lauren분형、분화정도、림상분기、침윤심도、림파결전이화원처전이적관계.방법 련속수집장치의학원부속화제의원위암절제술후조직표본80례,안조병리조직분형분위관상선암、점액선암、수양암급미만형암사조.응용면역조직화학SP법진행E-Cad검측,대E-Cad표체양성여위암적분화、전이등진행상관분석.결과 80례위암조직표본중E-Cad표체솔위55.00%,E-Cad재위암조직중적표체여위암Lauren분형、분화정도、림상분기、침윤심도、림파결전이화원처전이현저상관(P＜0.05),이여환자성별、년령、종류대소등삼수무상관성.E-Cad재유림파결전이적위암원발조화전이림파결중적표체솔분별위35.48%화32.26%.E-Cad적표체여유림파결전이적위암중적원발조화전이림파결정현저상관(r=0.4978,P＜0.05).결론 면역조직화학관찰발현구유침습성조직병이학특정적종류상유E-Cad표체,E-Cad적표체여위암분화、침습전이밀절상관.
Objective To investigate the expression of E-cadherin(E-cad)and the relationship with the Lauren classification,the degree of histological differentiation,the clinical stage,the depth of invasion,lymph node metastasis and distant metastasis of gastric cancer. Methods 80 cases architecture of gastric cancer and normal tissue were collected.The expression level of E-cad in 80 cases of gastric carcinomas and their metastatic lymph node tissues were examined by immunohistochemical assays.Results The expression rate of E-cad in 80 cases of gastric carcinomas Was 55.00%.The expression level of E-cad was positively correlated with the Lauren classification,the degree of histological differentiation,the clinical stage,the depth of invasion,lymph node metastasis and distant metastasis(P＜0.05),but Was not correlated to patients sex,age and tumor size.The expression rates of E-cad in metastatic gastric carcinoma of primary lesions and lymph nodes metastasis were 35.48%and 32.26%. respectively. Furthermore, E-cad expression in metastatic gastric carcinoma was significandy correlated with primary lesions and lymph node memstasis(r=0.4978,P＜0.05).Conclusion The expression level of E-cad in gastric carcinoma Was closely correlated with the degree of tumor differentiation,infiltration and transferring.
