中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
4期
480-483
,共4页
叶爱玲%颜勤明%柴泽音%高祖华%谢平平
葉愛玲%顏勤明%柴澤音%高祖華%謝平平
협애령%안근명%시택음%고조화%사평평
糖尿病,妊娠/代谢%视黄醇结合蛋白质类/代谢%C反应蛋白质/代谢%脂肪酸类/代谢%胰岛素抗药性
糖尿病,妊娠/代謝%視黃醇結閤蛋白質類/代謝%C反應蛋白質/代謝%脂肪痠類/代謝%胰島素抗藥性
당뇨병,임신/대사%시황순결합단백질류/대사%C반응단백질/대사%지방산류/대사%이도소항약성
Diabetes,gestational/ME%Retinol-binding proteins/ME%C-reactive protein/ME%Fatty acids/ME%Insulin resistance
目的 探讨RBP-4与妊娠期糖尿病患者炎症因子超敏C反应蛋白(hs-CRP)、游离脂肪酸(FFA)及胰岛素抵抗的关系.方法 97例就诊产科及内分泌科门诊的妊娠期女性,正常葡萄糖耐量(NGT)组50例、糖耐量异常(IGT)组20例、妊娠期糖尿病组(GDM)组27例,按BMI分为正常体重组(NW)42例及超重/肥胖组(OW/OB)55例.用ELISA测定血清RBP-4.全自动生化仪检测hs-CRP、游离脂肪酸(FFA)、甘油三酯(TG)、总胆固醇(TC);化学发光法检测胰岛素.结果 IGT组、GDM组ln(HOMA-IR)、FFA、ln(hs-CRP)均高于NGT组(P＜0.05),OW/OB组的FFA[(0.90±0.31)mmol/L vs (0.71±0.28)mmol/L,t＝2.73,P＜0.05]、ln(hs-CRP)(0.62±1.00 vs -0.17±1.07,t＝2.90,P＜0.05)、ln(HOMA-IR)、lnRBP(0.56±0.27 vs 0.30±0.14,t＝2.86,P＜0.05)高于NW组,差异有统计学意义.单因素简单相关分析显示,GDM组与OW/OB组中,lnRBP-4与FFA及ln(hs-CRP)均呈正相关(r＝0.231,0.237,0.371,0.247,P＜0.05).而NGT、IGT组及NW组lnRBP-4与FFA、ln(hs-CRP)无相关.NGT组、OW/OB组lnRBP-4与ln(HOMA-IR)呈正相关(r＝0.276,0.290,P＜0.05).IGT组、GDM组及NW组lnRBP-4与ln(HOMA-IR)均无相关.逐步多元线性回归分析显示,ln(hs-CRP)、FFA、ln(HOMA-IR)均非lnRBP-4的独立影响因素.结论 在GDM患者中,RBP-4可作为一种新的炎症标志物.
目的 探討RBP-4與妊娠期糖尿病患者炎癥因子超敏C反應蛋白(hs-CRP)、遊離脂肪痠(FFA)及胰島素牴抗的關繫.方法 97例就診產科及內分泌科門診的妊娠期女性,正常葡萄糖耐量(NGT)組50例、糖耐量異常(IGT)組20例、妊娠期糖尿病組(GDM)組27例,按BMI分為正常體重組(NW)42例及超重/肥胖組(OW/OB)55例.用ELISA測定血清RBP-4.全自動生化儀檢測hs-CRP、遊離脂肪痠(FFA)、甘油三酯(TG)、總膽固醇(TC);化學髮光法檢測胰島素.結果 IGT組、GDM組ln(HOMA-IR)、FFA、ln(hs-CRP)均高于NGT組(P＜0.05),OW/OB組的FFA[(0.90±0.31)mmol/L vs (0.71±0.28)mmol/L,t＝2.73,P＜0.05]、ln(hs-CRP)(0.62±1.00 vs -0.17±1.07,t＝2.90,P＜0.05)、ln(HOMA-IR)、lnRBP(0.56±0.27 vs 0.30±0.14,t＝2.86,P＜0.05)高于NW組,差異有統計學意義.單因素簡單相關分析顯示,GDM組與OW/OB組中,lnRBP-4與FFA及ln(hs-CRP)均呈正相關(r＝0.231,0.237,0.371,0.247,P＜0.05).而NGT、IGT組及NW組lnRBP-4與FFA、ln(hs-CRP)無相關.NGT組、OW/OB組lnRBP-4與ln(HOMA-IR)呈正相關(r＝0.276,0.290,P＜0.05).IGT組、GDM組及NW組lnRBP-4與ln(HOMA-IR)均無相關.逐步多元線性迴歸分析顯示,ln(hs-CRP)、FFA、ln(HOMA-IR)均非lnRBP-4的獨立影響因素.結論 在GDM患者中,RBP-4可作為一種新的炎癥標誌物.
목적 탐토RBP-4여임신기당뇨병환자염증인자초민C반응단백(hs-CRP)、유리지방산(FFA)급이도소저항적관계.방법 97례취진산과급내분비과문진적임신기녀성,정상포도당내량(NGT)조50례、당내량이상(IGT)조20례、임신기당뇨병조(GDM)조27례,안BMI분위정상체중조(NW)42례급초중/비반조(OW/OB)55례.용ELISA측정혈청RBP-4.전자동생화의검측hs-CRP、유리지방산(FFA)、감유삼지(TG)、총담고순(TC);화학발광법검측이도소.결과 IGT조、GDM조ln(HOMA-IR)、FFA、ln(hs-CRP)균고우NGT조(P＜0.05),OW/OB조적FFA[(0.90±0.31)mmol/L vs (0.71±0.28)mmol/L,t＝2.73,P＜0.05]、ln(hs-CRP)(0.62±1.00 vs -0.17±1.07,t＝2.90,P＜0.05)、ln(HOMA-IR)、lnRBP(0.56±0.27 vs 0.30±0.14,t＝2.86,P＜0.05)고우NW조,차이유통계학의의.단인소간단상관분석현시,GDM조여OW/OB조중,lnRBP-4여FFA급ln(hs-CRP)균정정상관(r＝0.231,0.237,0.371,0.247,P＜0.05).이NGT、IGT조급NW조lnRBP-4여FFA、ln(hs-CRP)무상관.NGT조、OW/OB조lnRBP-4여ln(HOMA-IR)정정상관(r＝0.276,0.290,P＜0.05).IGT조、GDM조급NW조lnRBP-4여ln(HOMA-IR)균무상관.축보다원선성회귀분석현시,ln(hs-CRP)、FFA、ln(HOMA-IR)균비lnRBP-4적독립영향인소.결론 재GDM환자중,RBP-4가작위일충신적염증표지물.
Objective To investigate the relationships between serum concentration of RBP-4 and inflammatory factors,insulin resistance in patients with gestational diabetes mellitus.Methods 20 patients newly diagnosed with impaired glucose tolerance (IGT),27 patients newly diagnosed with gestational diabetes mellitus(GDM) and 50 subjects with normal glucose tolerance(NGT) were enrolled in this cross-sectional study.Additionally,another subset analysis was performed,subjects were divided on the basis of BMI into normal weight (NW) and overweight or obesity (OW/OB).Serum RBP-4 was measured with ELISA;serum concentrations of hs-CRP,free fatty acids (FFA),triglyeride(TG),total cholesterol (TC) and insulin were measured in fasting status.Insulin resistance was assessed by HOMA-IR.Results Ln(HOMA-IR) and the concentrations of FFA,ln(hs-CRP) in IGT or in GDM were significantly higher than that of NGT(P＜0.05).In the group of OW/OB,FFA[(0.90±0.31)mmol/L vs (0.71±0.28)mmol/L,t＝2.73,P＜0.05)],ln(hs-CRP)(0.62±1.00 vs -0.17±1.07,t＝2.90,P＜0.05),ln(HOMA-IR),lnRBP(0.56±0.27 vs 0.30±0.14,t＝2.86,P＜0.05)were significantly higher than that of NW.In the group of GDM,lnRBP-4 showed a positive relationship with FFA (r＝0.231,P＜0.05)and ln(hs-CRP) (r＝0.237,P＜0.05).There was a positive relationship between lnRBP-4 and FFA(r＝0.371,P＜0.05) or ln(hs-CRP)(r＝0.247,P＜0.05) in the group of OW/OB,but no association in the group of NGT,IGT or NW.There was no relationship between lnRBP-4 and ln(HOMA-IR) in IGT,GDM and NW,while in the group of NGT and OW/OB,lnRBP-4 showed a positive relationship with ln(HOMA-IR) (r＝0.276,0.290,P＜0.05).In a multiple linear regression analysis,ln(hs-CRP),FFA or ln(HOMA-IR) was not the independent factor of lnRBP-4 in any group.Conclusions In patients with gestational diabetes mellitus,lnRBP-4 may be a new marker of inflammation.
